Efficacy and safety of probiotics in the treatment of irritable bowel syndrome: A systematic review and meta-analysis of randomised clinical trials using ROME IV criteria

Konstantis, Georgios; Efstathiou, Stylianos; Pourzitaki, Chryssa; Kitsikidou, Elisavet; Chourdakis, M.

doi:10.1016/j.clnu.2023.03.019

Cited by 8 publications

(5 citation statements)

References 53 publications

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“…A meta-analysis of patients with IBS meeting Rome IV criteria included 6 RCTs of 9 different probiotic strains (51). All IBS subtypes were included, and separate analyses for the different subtypes were not reported.…”

Section: Irritable Bowel Syndromementioning

confidence: 99%

Non-prescription Therapeutics

Weingarden,

2024

Am J Gastroenterol

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Section: Irritable Bowel Syndromementioning

confidence: 99%

Non-prescription Therapeutics

Weingarden,

2024

Am J Gastroenterol

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“…In this context, the use of different therapeutic tools, such as prebiotics, probiotics, synbiotics, postbiotics, and also fecal transplants, need to be deepened in order to establish their role in the upcoming years, as new evidence points the way toward increasingly effective treatments, especially for some of these, while, for others, conflicting or biased results have emerged. Particularly concerning probiotics, data from the literature show great heterogeneity and no univocal agreement on their clinical application in the IBS setting [195].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Gut Dysbiosis in Irritable Bowel Syndrome: A Narrative Review on Correlation with Disease Subtypes and Novel Therapeutic Implications

Napolitano,

Fasulo,

Ungaro

et al. 2023

Microorganisms

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Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits. It can be subclassified in different subtypes according to the main clinical manifestation: constipation, diarrhea, mixed, and unclassified. Over the past decade, the role of gut microbiota in IBS has garnered significant attention in the scientific community. Emerging research spotlights the intricate involvement of microbiota dysbiosis in IBS pathogenesis. Studies have demonstrated reduced microbial diversity and stability and specific microbial alterations for each disease subgroup. Microbiota-targeted treatments, such as antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and even diet, offer exciting prospects for managing IBS. However, definitive conclusions are hindered by the heterogeneity of these studies. Further research should focus on elucidating the mechanisms, developing microbiome-based diagnostics, and enabling personalized therapies tailored to an individual’s microbiome profile. This review takes a deep dive into the microscopic world inhabiting our guts, and its implications for IBS. Our aim is to elucidate the complex interplay between gut microbiota and each IBS subtype, exploring novel microbiota-targeted treatments and providing a comprehensive overview of the current state of knowledge.

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“…A recent RCT confirmed that Bifidobacterium quadruple viable tablets effectively alleviated abdominal pain and diarrhea for patients with diarrhea-predominant IBS (IBS-D) [15]. Two meta-analyses indicated that probiotics had beneficial effects on abdominal pain and bloating [16,17].…”

Section: Introductionmentioning

confidence: 98%

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis

Xie,

Luo,

Deng

et al. 2023

Nutrients

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Irritable bowel syndrome (IBS) is a common gastrointestinal disease. The efficacy of different probiotics in treating IBS remains controversial. This network meta-analysis aimed to compare and rank the outcome-specific efficacy of different probiotic strains or combinations in adults with IBS. We searched the literature up to June 2023. Randomized controlled trials (RCTs) that evaluated the efficacy of probiotics in IBS were included. A frequentist framework was used to perform this study. In total, 9253 participants from 81 RCTs were included in the study. Four probiotic strains and five mixtures were significantly superior to placebo in improving IBS Symptom Severity Scale, among which Lactobacillus acidophilus DDS-1 ranked first (surface under the cumulative ranking, SUCRA, 92.9%). A mixture containing five probiotics (SUCRA, 100%) ranked first in improving the IBS-Quality of life. Bacillus coagulans MTCC 5856 (SUCRA, 96.9%) and Bacillus coagulans Unique IS2 (SUCRA, 92.6%) were among the most effective probiotics for improving abdominal pain. Three probiotic strains and two mixtures were effective in alleviating abdominal bloating. Four probiotic strains and a mixture were significantly superior to placebo in reducing the bowel movement frequency in diarrhea-predominant IBS (IBS-D). Bacillus coagulans MTCC 5856 (SUCRA, 99.6%) and Saccharomyces cerevisiae CNCM I-3856 (SUCRA, 89.7%) were among the most effective probiotics for improving the Bristol stool form scale of IBS-D. Only some probiotics are effective for particular outcomes in IBS patients. This study provided the first ranking of outcome-specific efficacy of different probiotic strains and combinations in IBS. Further studies are needed to confirm these results.

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Efficacy and safety of probiotics in the treatment of irritable bowel syndrome: A systematic review and meta-analysis of randomised clinical trials using ROME IV criteria

Cited by 8 publications

References 53 publications

Non-prescription Therapeutics

Non-prescription Therapeutics

Gut Dysbiosis in Irritable Bowel Syndrome: A Narrative Review on Correlation with Disease Subtypes and Novel Therapeutic Implications

Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis

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