Efficacy and safety of post-auricular injection of methylprednisolone sodium succinate and lidocaine in the treatment of acute tinnitus, and its effect on sleep quality

Abstract

Purpose: To study the efficacy and safety of post-auricular injection of methylprednisolone sodium succinate plus lidocaine in the treatment of acute tinnitus, and its effect on sleep quality.Methods: Eighty acute tinnitus patients admitted to Nanfang Hospital, Southern Medical University, Guangzhou, China from January 2020 to June 2021, served as subjects for this retrospective analysis. The patients were equally assigned to a reference group given postauricular injection of lidocaine, and a research group treated with post-auricular injection of methylprednisolone sodium succinate in combination with lidocaine. Treatment efficacy values in the two groups of patients were determined and compared.Results: Total treatment effectiveness values in patients in the research group after one course of treatment, and at three months post-treatment, were significantly higher than the corresponding values in the reference group (p < 0.05). After treatment, the two groups had markedly improved Tinnitus Handicap Inventory (THI) scores, although patients in the research group had lower scores than those in reference group (p < 0.05). There were significant decreases in post-treatment pure tone threshold and Pittsburgh sleep quality index (PSQI) in the two groups of patients, with lower values in the research group than in the reference group (p < 0.05). There were no obvious adverse drug reactions during treatment and during 3-month follow-up period.Conclusion: Post-auricular injection of methylprednisolone sodium succinate and lidocaine effectively improved the clinical efficacy and the sleep quality of acute tinnitus patients. It is a simple and highly safe operation which merits clinical application.

Therapeutic efficacy of methylprednisolone sodium succinate via diverse administration routes for mid- to high-frequency sudden sensorineural hearing loss

“…Currently, the main treatment options for high-frequency SSNHL involve glucocorticoids and drugs that regulate inner ear circulation. Early and effective treatment is crucial for hearing recovery and prognosis improvement[ 4 ]. Methylprednisolone sodium succinate (MPSS), a newly developed glucocorticoid medication, has demonstrated significant efficacy due to its anti-inflammatory, antiallergic, and immunosuppressive effects.…”

“…However, what sets this study apart was the comprehensive approach used to compare not only the systemic and IT routes of MPSS administration but also the combined IT administration of neurotrophic factors and vasodilators. In addition to this novel aspect, our study aimed to evaluate the potential synergistic effects of the combination of MPSS with adjunctive therapies, which have shown promise in preclinical and early clinical studies, to provide a more holistic perspective on the treatment outcomes of SSNHL patients[ 4 ].…”