Efficacy and safety of plasma gel versus platelet-rich plasma in periorbital rejuvenation: a comparative split-face clinical and Antera 3D camera study

Does platelet-rich plasma promote facial rejuvenation? Revising the latest evidence in a narrative review

“…While both authors described that PPP and PRP reduced tear through, a lighting effect on periorbital dark circles was only noticed by Neinaa et al . [ 21 ] In both studies, the direct comparison between the visual impact of PPP and PRP seemed to favor the former. Treatment with PPP was associated with 10% severe and 17.5% moderate complications.…”

“…Initial search retrieved 539 articles and from these, 523 were excluded based on title, abstract and exclusion criteria. A total of 16 articles were included in the review,[ 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 ] with an aggregate of 586 participants [ Table 1 ]. Among the 16 articles, in 10 studies (62.5%), PRP was injected in monotherapy, in five studies (31.2%), PRP was topically applied following ablative laser treatment (CO 2 or erbium), microneedling or electroporation and in one study (6.3%) PRP was injected in conjunction with autologous fat.…”

“…Moreover, PRP had a better effect on the external cellular matrix of the skin. Neinaa et al [ 21 ] and Diab et al [ 30 ] published their results in 2020 and 2021, respectively, comparing PRP with PPP gel using a split-face approach. Studies were aimed at the periorbital area, focusing on wrinkle and hyperpigmentation improvement.…”

Management of post‐inflammatory hyperpigmentation in skin of color: A short review

“…PRP has been proposed to decrease pigmentation by inhibiting prostaglandin‐E2 expression and tyrosinase activity, potentially suggesting a role for PRP in treating PIH 28 . A recent split‐faced study evaluating the role of PRP in periorbital hyperpigmentation suggests a role for PRP as an alternative treatment option for hyperpigmentation in those who cannot tolerate chemical peels 29,30 31,32 .…”

“…28 A recent split-faced study evaluating the role of PRP in periorbital hyperpigmentation suggests a role for PRP as an alternative treatment option for hyperpigmentation in those who cannot tolerate chemical peels. 29,30 TXA has also been shown to be efficacious in treating melasma due to its tyrosinase inhibitory activity with oral TXA 500mg twice daily showing improvement in melasma severity without significant adverse events, which suggests it may have a role in other pigmentation disorders like PIH. 31,32 Lastly, botanical products such as bakuchiol, an extract from the tree Psoralea corylifolia, which has been found to have anti-inflammatory and anti-oxidative properties, have also gained popularity in the treatment of PIH.…”