Efficacy and Safety of Picosecond-Domain neodymium-Doped Yttrium Aluminum Garnet Laser Treatment on Various causes of Traumatic Tattoos

Goo, Boncheol; Cho, Sung Bin

doi:10.25289/ml.2016.5.2.90

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…8 In addition, it has been also demonstrated that picosecond-domain Nd:YAG laser therapy was highly efficacious in the treatment of traumatic tattoos in Asians with great safety profiles. 9 In our case, we successfully treated hyperpigmented traumatic tattoos by applying 1,064-nm picosecond Nd:YAG laser. For covering linearly depressed area, we treated the patient by simply incorporating a novel holographic beam-splitter to achieve fractional picosecond laser beams.…”

Section: Discussionmentioning

confidence: 99%

Pigmented and Depressed Facial Scar after an External Injury: Successful Treatment with 1,064-nm Picosecond Neodymium: Yttrium-Aluminum-Garnet Laser Simply Combined with a Fractional Beam-Splitter Handpiece

Chung¹,

Lee²,

Kim

2018

Medical Lasers

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A 29-year-old man presented with facial scars one and half years after an external injury. A physical examination revealed a slightly depressed linear scar with bluish brown pigments from traumatic tattoos on the nasal root. He was treated with a 1,064-nm picosecond neodymium:yttriumaluminum-garnet (Nd:YAG) laser combined with a fractional picosecond mode by integrating a holographic beam splitter handpiece. After five sessions of this simple combined treatment modality, the patient achieved significant clinical improvement with no downtime period. To the best of the authors' knowledge, this is the first case of the effective treatment of facial scars after a skin injury using a 1,064-nm picosecond Nd:YAG laser together with a simple combination of a fractional beam splitter handpiece, successfully targeting both the traumatic tattoos and depressed scars. Key words

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Section: Discussionmentioning

confidence: 99%

Pigmented and Depressed Facial Scar after an External Injury: Successful Treatment with 1,064-nm Picosecond Neodymium: Yttrium-Aluminum-Garnet Laser Simply Combined with a Fractional Beam-Splitter Handpiece

Chung¹,

Lee²,

Kim

2018

Medical Lasers

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“…Recently, compared with microsecond-domain lasers, 1064 nm picosecond-and nanosecond-domain neodymium (Nd):YAG lasers have been introduced to create fast photothermal reactions and cause less skin impairment [12]. These lasers are used to treat tattoo, photoaging, and acne scarring in clinics [13]. To decrease thermal damage, the picosecond or nanosecond pulse duration is shorter than the thermal relaxation time of the skin tissue.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Delivery of Cosmeceutical Peptides Enhanced by Picosecond- and Nanosecond-Domain Nd:YAG Lasers with Quick Recovery of the Skin Barrier Function: Comparison with Microsecond-Domain Ablative Lasers

et al. 2022

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Picosecond or nanosecond-domain non-ablative lasers generate faster photothermal effects and cause less injury than microsecond lasers. In this study, we investigated the enhancing effect of 1064 nm picosecond- and nanosecond-domain neodymium (Nd):yttrium–aluminum–garnet (YAG) lasers on the cutaneous delivery of cosmeceutical peptides. Microsecond-domain fractional ablative CO2 and fully ablative erbium (Er):YAG lasers were also used for comparison. In the Franz diffusion cell study, pig or mouse skin was treated with a laser before exposure to palmitoyl tripeptide (PT)-1, PT-38, and copper tripeptide (CT)-1 at a concentration of 150 μM. Psoriasiform, atopic dermatitis (AD)-like, and photoaged skins were also developed as permeation barriers. The non-ablative laser elicited the ultrastructural disruption of the stratum corneum and epidermal vacuolation. All laser modalities significantly increased the skin permeation of peptides in vitro. The non-ablative laser chiefly enhanced peptide delivery to the receptor compartment, whereas the ablative laser mainly increased the intracutaneous peptide deposition. The picosecond- and nanosecond-domain Nd:YAG lasers elevated the amount of PT-1 in the receptor up to 40- and 22-fold compared with untreated skin, respectively. Laser treatment promoted peptide delivery in barrier-deficient and inflamed skins, although this enhancement effect was less than that observed in healthy skin. Fluorescence microscopy indicated the capability of the non-ablative laser to deliver peptides to deeper skin strata. The ablative laser confined the peptide distribution in the epidermis. Confocal microscopy showed that peptides penetrated the skin along the microdots created by the fractional Nd:YAG and CO2 lasers. The skin barrier function determined by transepidermal water loss suggested quick recovery when using a nanosecond-domain laser (within 4 h). A longer period was needed for the skin treated with the fully ablative Er:YAG laser (76–84 h). Nanosecond non-ablative laser-facilitated peptide delivery may become an efficient and safe approach for cosmeceutical applications.

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Efficacy and Safety of Picosecond-Domain neodymium-Doped Yttrium Aluminum Garnet Laser Treatment on Various causes of Traumatic Tattoos

Cited by 2 publications

References 20 publications

Pigmented and Depressed Facial Scar after an External Injury: Successful Treatment with 1,064-nm Picosecond Neodymium: Yttrium-Aluminum-Garnet Laser Simply Combined with a Fractional Beam-Splitter Handpiece

Pigmented and Depressed Facial Scar after an External Injury: Successful Treatment with 1,064-nm Picosecond Neodymium: Yttrium-Aluminum-Garnet Laser Simply Combined with a Fractional Beam-Splitter Handpiece

Cutaneous Delivery of Cosmeceutical Peptides Enhanced by Picosecond- and Nanosecond-Domain Nd:YAG Lasers with Quick Recovery of the Skin Barrier Function: Comparison with Microsecond-Domain Ablative Lasers

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