Abstract:Background: Multi-agent chemotherapy is the primary treatment for acute lymphoblastic leukemia (ALL), of which the asparaginase including Escherichia coli L-asparaginase (E. coli L-Asp) and Pegylated-asparaginase (PEG-Asp) is a cornerstone component. The study aimed to conduct a meta-analysis to compare the efficacy and safety of PEG-Asp with E. coli L-Asp in Chinese children with ALL. Methods: A systematic literature search was conducted to collect randomized controlled trials (RCTs) on PEG-Asp versus E. coli… Show more
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