2020
DOI: 10.3389/fped.2019.00568
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Efficacy and Safety of Paracetamol for Patent Ductus Arteriosus Closure in Preterm Infants: An Updated Systematic Review and Meta-Analysis

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Cited by 22 publications
(26 citation statements)
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“…More than 76% of the cases received complete PDA closure in case series and reported PDA closure rates with paracetamol in RCTs ranged from 72.5 to 81.2 % with few incidences of elevated liver enzymes.7 A systematic review and metaanalysis conducted by Yingqi Xiao in 2020 concluded that paracetamol induces early patent ductus arteriosus closure without significant side effects. 8 The result of the meta analysis was similar to our result which had no short term side effects whatsoever during the course of treatment.…”
Section: Discussionsupporting
confidence: 86%
“…More than 76% of the cases received complete PDA closure in case series and reported PDA closure rates with paracetamol in RCTs ranged from 72.5 to 81.2 % with few incidences of elevated liver enzymes.7 A systematic review and metaanalysis conducted by Yingqi Xiao in 2020 concluded that paracetamol induces early patent ductus arteriosus closure without significant side effects. 8 The result of the meta analysis was similar to our result which had no short term side effects whatsoever during the course of treatment.…”
Section: Discussionsupporting
confidence: 86%
“…Two systematic reviews comparing paracetamol to ibuprofen (oral or intravenous) showed that there was a significant difference favouring paracetamol in creatinine levels, urine output, platelet count, serum bilirubin and incidence of gastrointestinal bleeding. 2,3 This study did not replicate these findings. This again highlights the fact that safety data for paracetamol use are still emerging.…”
contrasting
confidence: 55%
“…Paracetamol was found to have less duration required for PDA closure while there were less number of patients with gastrointestinal bleeding and hyperbilirubinemia. 22 Our study had some limitations as well. This was a single center study with comparatively small sample size so findings of this study cannot be generalized.…”
Section: Discussionmentioning
confidence: 93%