Efficacy and safety of noninvasive focused ultrasound for treatment of subcutaneous adiposity in healthy women

Fonseca, V.; Campos, Priscila Soares; Certo, Thays Fernanda; de-Faria, Luana Taís; Juliano, Priscila Bianchi; Cintra, Dennys Esper; Liebano, Richard Eloin; Silva, Caroline da; Guidi, Renata Michelini; Sant’Ana, Estela

doi:10.1080/14764172.2018.1511907

Cited by 12 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, macrophages are recruited to the injured tissue and an inflammatory response occurs due to chemotactic signals and tissue damage. This effect did not affect adjacent tissue, which demonstrated in several previous studies 12,13 . Most lipids and cellular debris from the procedure are removed within 12 weeks, which results in an overall reduction in the volume of adipose tissue–treated areas 14 …”

Section: Background and Objectivesmentioning

confidence: 64%

“…This effect did not affect adjacent tissue, which demonstrated in several previous studies. 12,13 Most lipids and cellular debris from the procedure are removed within 12 weeks, which results in an overall reduction in the volume of adipose tissue-treated areas. 14 To date, the therapeutic effect of HIFU on abdominal obesity has been reported; however, there have been few studies on the effects of HIFU on other sites such as the upper arm and thigh.…”

Section: Backg Round and Objec Tive Smentioning

confidence: 99%

See 1 more Smart Citation

High‐intensity focused ultrasound treatment for excessive subcutaneous fat in abdomen, upper arms, and thigh: A pilot study

Lee

Bang

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background High‐intensity focused ultrasound (HIFU) has been recently introduced as a non‐invasive therapeutic modality for controlling excessive subcutaneous fat. Objective The efficacy and safety of the HIFU device for sculpting the abdomen, upper arm, and thigh were evaluated. Materials and Methods Ten subjects with more than 10 mm of subcutaneous fat in the abdomen, upper arm, and/or thigh were recruited. We evaluate mean change in the thickness and circumference of subcutaneous fat of each treated area measured using ultrasound 12 weeks after the procedure, the degree of pain, and subject and practitioner satisfaction 12 weeks after the procedure. Results The mean change of subcutaneous fat thickness in the abdomen, upper arm, and thigh measured using ultrasound 12 weeks after the procedure was −4.33 ± 2.42, −1.86 ± 1.35, and −1.86 ± 1.35 mm, respectively. Compared with pretreatment, subcutaneous fat thickness of the abdomen and upper arm was significantly reduced (p = 0.0020 and p = 0.0004, respectively), but not in the thigh (p = 0.0716). Highest patient satisfaction was for the abdomen. Pain was generally tolerable. Conclusion The results from the present study indicate HIFU can be an effective and safe therapeutic modality for removing excessive subcutaneous fat in humans.

show abstract

Section: Background and Objectivesmentioning

confidence: 64%

Section: Backg Round and Objec Tive Smentioning

confidence: 99%

High‐intensity focused ultrasound treatment for excessive subcutaneous fat in abdomen, upper arms, and thigh: A pilot study

Lee

Bang

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…Studies investigating the efficacy of abdominal laser treatments 19,20 reported a fat thickness reduction ranging from 11.5 to 17 percent. For high-intensity focused ultrasound, the published results [21][22][23][24] are between 11.7 and 26.4 percent of fat thickness reduction.…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency Heating and High-Intensity Focused Electromagnetic Treatment Delivered Simultaneously: The First Sham-Controlled Randomized Trial

Samuels

Katz

Weiß

2022

Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Background: Radiofrequency-based and high-intensity focused electromagnetic (HIFEM)-based devices have proved effective and safe for abdominal body shaping. Radiofrequency is known to reduce adipose tissue, whereas HIFEM treatment is effective for muscle definition. The authors investigated the efficacy of a novel device delivering synchronized radiofrequency and HIFEM treatment simultaneously for abdominal toning and fat reduction. Methods: Seventy-two patients were enrolled and randomly divided into active ( n = 48; age, 45.5 ± 13.0 years) and sham groups ( n = 24; age, 44.6 ± 12.3 years). Both groups received three treatments on the abdomen once a week. The intensity in the active group was set to maximum tolerable level; in the sham group, the intensities were set to 5 percent. Ultrasound images were taken before treatment and at 1, 3, and 6 months after treatment to examine changes in subcutaneous fat and rectus abdominis muscle thickness. Digital photographs were taken, and satisfaction and therapy comfort were assessed. Results: Ultrasound images of the active group at 1 month showed significant ( p < 0.05) reduction in adipose tissue thickness by 20.5 percent (4.8 ± 2.6 mm), whereas rectus abdominis muscle thickness increased by 21.5 percent (2.0 ± 0.8 mm). Results at 3 months improved to 28.3 percent (7.6 ± 3.7 mm) and 24.2 percent (2.3 ± 0.9 mm), respectively. Improvements were maintained at 6 months after treatment in the active group, whereas the sham group showed no significant changes. Treatments were found to be comfortable. The active group showed higher satisfaction with outcomes. Conclusion: Active treatment utilizing simultaneous application of radiofrequency and HIFEM therapy resulted in a significant increase in rectus abdominis thickness and subcutaneous fat reduction, exceeding previously published results for separate HIFEM and radiofrequency treatments. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.

show abstract

“…This study also used T2 mapping to demonstrate a measurable increase in T2 relaxivity in the treated fat compared to the remote fat that occurred immediately and was sustained at 60 mins. Clinical studies have been limited to fat thickness measurements on ultrasound ( 42 , 43 ). Imaging the thermal injury and post-treatment scar within fatty tissues in vivo has not been documented.…”

Section: Fatmentioning

confidence: 99%

Tissue specific considerations in implementing high intensity focussed ultrasound under magnetic resonance imaging guidance

et al. 2022

View full text Add to dashboard Cite

High-intensity focused ultrasound can ablate a target permanently, leaving tissues through which it passes thermally unaffected. When delivered under magnetic resonance (MR) imaging guidance, the change in tissue relaxivity on heating is used to monitor the temperatures achieved. Different tissue types in the pre-focal beam path result in energy loss defined by their individual attenuation coefficients. Furthermore, at interfaces with different acoustic impedances the beam will be both reflected and refracted, changing the position of the focus. For complex interfaces this effect is exacerbated. Moreover, blood vessels proximal to the focal region can dissipate heat, altering the expected region of damage. In the target volume, the temperature distribution depends on the thermal conductivity (or diffusivity) of the tissue and its heat capacity. These are different for vascular tissues, water and fat containing tissues and bone. Therefore, documenting the characteristics of the pre-focal and target tissues is critical for effective delivery of HIFU. MR imaging provides excellent anatomic detail and characterization of soft tissue components. It is an ideal modality for real-time planning and monitoring of HIFU ablation, and provides non-invasive temperature maps. Clinical applications involve soft-tissue (abdomino-pelvic applications) or bone (brain applications) pre-focally and at the target (soft-tissue tumors and bone metastases respectively). This article addresses the technical difficulties of delivering HIFU effectively when vascular tissues, densely cellular tissues, fat or bone are traversed pre-focally, and the clinical applications that target these tissues. The strengths and limitations of MR techniques used for monitoring ablation in these tissues are also discussed.

show abstract

Efficacy and safety of noninvasive focused ultrasound for treatment of subcutaneous adiposity in healthy women

Cited by 12 publications

References 23 publications

High‐intensity focused ultrasound treatment for excessive subcutaneous fat in abdomen, upper arms, and thigh: A pilot study

High‐intensity focused ultrasound treatment for excessive subcutaneous fat in abdomen, upper arms, and thigh: A pilot study

Radiofrequency Heating and High-Intensity Focused Electromagnetic Treatment Delivered Simultaneously: The First Sham-Controlled Randomized Trial

Tissue specific considerations in implementing high intensity focussed ultrasound under magnetic resonance imaging guidance

Contact Info

Product

Resources

About