“…Clinical studies have shown that oral NK 1 RAs are generally well tolerated with few additional AEs, mostly mild, when compared to 5-HT 3 RA plus dexamethasone (Table 3 [74,99,100] and Table 4 [8,72,73,81,83,95,96]). The most frequent AEs associated with oral NK 1 RAs are fatigue, hiccups, headache, and constipation [8,[72][73][74][75]81,86,87,95,96,105,106]. No significant effects on the QT interval were observed at supratherapeutic doses of NK 1 RAs [39,41,42,44,107].…”