Efficacy and safety of nanoparticles of glibenclamide and organomodified layered double hydroxides in diabetics rats

Leão, Amanda Damasceno; Silva, Juliano Ribeiro da; Agostini, Jotele Fontana; Santo, Glaucia Dal; Vieira, Lêucio Duarte; Neto, Jacinto da Costa Silva; Ramos, Katharina Rodrigues de Lima Porto; Silva, Teresinha Gonçalves da; Alvarez-Lorenzo, Carmen; Wanderley, Almir Gonçalves; Soares-Sobrinho, José Lamartine

doi:10.1016/j.ijpharm.2023.122678

International Journal of Pharmaceutics

2023

DOI: 10.1016/j.ijpharm.2023.122678

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Efficacy and safety of nanoparticles of glibenclamide and organomodified layered double hydroxides in diabetics rats

Amanda Damasceno Leão

Juliano Ribeiro da Silva

Jotele Fontana Agostini

et al.

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2024

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Li,

Soyhan,

Warszawik

et al. 2024

Advanced Science

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Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in the structural composition and ease of surface modification of LDHs makes it possible to develop specifically functionalized LDHs to meet the needs of different applications. In this review, the recent advances of LDHs for biomedical applications, which include LDH‐based drug delivery systems, LDHs for cancer diagnosis and therapy, tissue engineering, coatings, functional membranes, and biosensors, are comprehensively discussed. From these various biomedical research fields, it can be seen that there is great potential and possibility for the use of LDHs in biomedical applications. However, at the same time, it must be recognized that the actual clinical translation of LDHs is still very limited. Therefore, the current limitations of related research on LDHs are discussed by combining limited examples of actual clinical translation with requirements for clinical translation of biomaterials. Finally, an outlook on future research related to LDHs is provided.

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Li,

Soyhan,

Warszawik

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

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Efficacy and safety of nanoparticles of glibenclamide and organomodified layered double hydroxides in diabetics rats

Cited by 1 publication

References 52 publications

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

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