Efficacy and safety of multimodal treatment in nocturnal enuresis - A retrospective cohort study

Meyer, Sonja; Jørgensen, Cecilie Siggaard; Kamperis, Konstantinos; Andersen, René Frydensberg; Pedersen, Malthe Jessen; Faerch, Mia; Rittig, Søren

doi:10.1016/j.jpurol.2021.03.005

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…Even if the physician can successfully treat these patients, there is almost no information regarding pharmacological withdrawal strategies. [1][2][3] In this regard, I greatly appreciate the work of Hussiny and colleagues published in this month's Journal. This paper gives us an honest appraisal of fluoxetine's usefulness for the treatment of refractory PMNE; it exposes the medication's association with tachyphylaxis and lays the foundation regarding how we may devise treatment plans to use this pharmacological agent in the future.…”

Section: Editorial Commentmentioning

confidence: 89%

“…Invariably, these individuals will have failed clinical trials involving almost all the standard current treatment modalities, eg, behavioral modification techniques, enuretic alarms, desmopressin, imipramine, antimuscarinics, mirabegron, the combination of indomethacin and furosemide, and multimodal therapy. 1 Patients with treatment-refractory PMNE, especially as they age into adulthood, face significant psychological and social stress regarding this embarrassing problem. In our experience, affected adults will frequently be reticent to seek treatment, choosing to adapt their lifestyle to hide the disorder by using protective undergarments and significant social ruses.…”

Section: Editorial Commentmentioning

confidence: 99%

“…Currently, the clinically recognized treatment options available for highly treatmentÀresistant patients with PMNE include assessment for and treatment of any sleep abnormalities that may exist, trials of clonidine, and now fluoxetine. [1][2][3] Unfortunately, medical treatment recommendations for this difficultto-treat patient population are based on small treatment numbers. They are also associated with a paucity of data regarding the long-term usage of these medications and the possible drug-drug interactions that might occur if polypharmacy is used for management.…”

Section: Editorial Commentmentioning

confidence: 99%

“…Even if the physician can successfully treat these patients, there is almost no information regarding pharmacological withdrawal strategies. 1-3…”

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confidence: 99%

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Editorial Comment

Husmann

2022

Journal of Urology

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Section: Editorial Commentmentioning

confidence: 89%

Section: Editorial Commentmentioning

confidence: 99%

Section: Editorial Commentmentioning

confidence: 99%

“…Even if the physician can successfully treat these patients, there is almost no information regarding pharmacological withdrawal strategies. 1-3…”

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confidence: 99%

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Editorial Comment

Husmann

2022

Journal of Urology

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“…Therefore interest has recently arisen for use of combination pharmacotherapy early in the course of this multimodal entity. 10 Clinical decision in an individual case depends on many factors especially the AFASS criteria of being Acceptable, Feasible, Affordable, Sustainable and Safe. AFASS criteria may not be totally scientific but is the practical answer especially in developing and poor countries.…”

Section: Amongst the Pharmacological Interventionsmentioning

confidence: 99%

“Efficacy of Combination drug therapy of Oxybutynin and Desmopressin in enuresis in children in comparison to one drug therapy or any other combination drug therapy : A Systematic review and Meta-analysis”

Hajela

Vinayak

Gupta

2022

Bangladesh J Med Sci

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Background: This Systematic review was undertaken to bring forward some solution to the old stubborn neglected problem of enuresis in children which appears to be left out in the race of scientific advancements. The pathogenesis of disease so far understood is supposed to be the result of three factors of Polyuria, Overactive bladder and difficulties in arousal from sleep. However pinpointing the extent and role of each one in an individual case is a difficult time and resource consuming job. The aim of study is to help front line clinicians in decision making in poor resource limited developing countries, so that children and families are not abandoned to suffer on their own without any hope for a speedy solution, when they come forward asking for help. Methods: We hypothesized that combination therapy of Desmopressin and oxybutynin in usual therapeutic doses at outset, might be a solution. To accumulate evidence an extensive search was done as per PRISMA 2020 guideline for properly designed double blind Randomized clinical trials to back up any such decision. Databases searched were PubMed, Embase, Google Scholar, Scopus and web of science. Clinical trial registry platforms, open access grey areas and cross references were also searched. Data obtained was analyzed by random effect model , at 95% confidence interval with Mantel Haenszel test for risk ratio. Protocol was registered at PROSPERO Results: There was lack of robust randomized data for any nodal network meta-analysis. Nine studies were included for analysis having experimental or Intervention arm as combination therapy versus Desmopressin mono drug therapy as comparator. Synthesis of data and meta-analysis was done using Cochrane Revman version 5.4 There was lack of studies for comparison to Oxybutynin and Imipramine mono drug therapy, hence they are discussed in tabular form only There is some hope in other combinations also in new entrants in the armamentarium against enuresis in children like Tolterodine, Solifenacin, Propiverine. A favorable outcome was observed for this combination therapy at outset in whatever studies we found, but risk of bias is there and superiority can be said as only marginal. More robust evidence is needed from scientific researchers for different pharmacological combination therapies at outset to decrease the gap from the point of seeking help to control of enuresis. Conclusion: We recommend trial of Desmopressin Oxybutynin combination therapy at the time of seeking help in resource poor developing countries to tackle this stigmatized socially unacceptable problem of children at present. This will also help in generating more robust data in favor or against any such decision for future reference and analysis. But we can say that the scientific fraternity is still far behind in properly designed randomized and blinded trials for any clear and evidence based medicine for this entity. Bangladesh Journal of Medical Science Vol. 21 No. 04 October’22 Page : 685-697

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Enuresis

Rittig

2022

Pediatric Nephrology

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Efficacy and safety of multimodal treatment in nocturnal enuresis - A retrospective cohort study

Cited by 8 publications

References 14 publications

Editorial Comment

Editorial Comment

“Efficacy of Combination drug therapy of Oxybutynin and Desmopressin in enuresis in children in comparison to one drug therapy or any other combination drug therapy : A Systematic review and Meta-analysis”

Enuresis

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