Efficacy and safety of moxibustion on cancer-related fatigue: a systematic review and meta-analysis of randomized controlled trials

Wang, Xiao-Qing; Qiao, Yue; Duan, Pei-Bei; Du, Shi-Zheng; Yang, Li-Hua

doi:10.1007/s00520-023-07977-z

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…The aggregated standardized mean difference (SMD) indicated a statistically significant association between moxibustion and alleviation of cancer-related fatigue. 41 Our study incorporates additional RCTs not covered in their research, and we have specifically narrowed inclusion criteria to focus on breast cancer patients. Additionally, unlike the aforementioned studies, we utilized databases from Korea and Japan, in addition to English and Chinese databases.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

Bae,

Kim,

Ahn

et al. 2024

Integr Cancer Ther

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Introduction: Breast cancer is the most commonly diagnosed cancer worldwide, and most patients experience fatigue. However, there are no effective treatments for cancer-related fatigue (CRF). Several randomized controlled trials (RCTs) have suggested that moxibustion improves CRF. We conducted a systematic review and meta-analysis to compare the differences in fatigue scale scores, quality of life, and clinical efficacy in patients with breast cancer who developed CRF and did versus did not receive moxibustion. Methods: RCTs were searched in 7 databases using a standardized search method from database inception to March 2023, and RCTs that met the inclusion criteria were selected. Results: Among 1337 initially identified RCTs, 10 RCTs involving 744 participants were selected for this study. The meta-analysis involved assessment of the revised Piper Fatigue Scale scores, Cancer Fatigue Scale scores, Karnofsky Performance Scale scores, Athens Insomnia Scale scores, clinical efficacy, and Qi deficiency syndrome scale scores. Compared with the control, moxibustion was associated with significantly better Piper Fatigue Scale scores ( P < 0.0001), quality of life [Karnofsky Performance Scale scores ( P < 0.0001)], clinical efficacy ( P = 0.0007), and Qi deficiency syndrome scale scores ( P = 0.02). Conclusions: Moxibustion improves CRF in patients with breast cancer. The efficacy of moxibustion should be further examined by high-quality studies in various countries with patients subdivided by their breast cancer treatment status. Registration: PROSPERO ID: CRD42023451292

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Section: Discussionmentioning

confidence: 99%

Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

Bae,

Kim,

Ahn

et al. 2024

Integr Cancer Ther

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Assessment of Quality of Reporting in Randomized Controlled Trials of Moxibustion for Chronic Diseases Using the Consolidated Standards of Reporting Trials and Standards for Reporting Interventions in Clinical Trials of Moxibustion Statements

Chen,

Deng,

Liu

et al. 2024

Complement Med Res

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Background: Moxibustion is clinically used for treating various chronic diseases; however, the reporting quality of current published RCTs of moxibustion is unclear. Objective: To assess the reporting quality of RCTs focusing on moxibustion as a treatment for chronic diseases. Methods: Seven databases were searched to identify relevant RCTs. Criteria for evaluating the reporting quality of standard RCT elements and moxibustion intervention-related information were developed based on the CONSORT statement and its STRICTOM extension, respectively. Multivariate regression models were used to investigate factors impacting reporting quality. Results: A total of 310 RCTs were included, with 41 (7.6%) published in English journals and 269 (92.4%) in Chinese journals. The median CONSORT and STRICTOM scores of these RCTs, with a maximum score of 100, were 41.2 and 62.9, respectively. RCTs with a later publication year and with protocol registration or ethical approval exhibited significantly higher CONSORT and STRICTOM scores. Higher CONSORT scores were also significantly associated with English-language publication, funding support, and inclusion of a safety evaluation, while higher STRICTOM scores were additionally associated with an active-control design. Conclusion: The reporting quality of RCTs focusing on moxibustion treatment for chronic diseases is subpar, with gradual but limited improvement over the last 25 years. To enhance the reporting quality of moxibustion RCTs, researchers should develop a comprehensive study protocol and standardize result reporting based on CONSORT and STRICTOM statements. Registration platforms, ethical approval organizations, funders, and journals can also contribute to this improvement by bolstering structured information reporting in the review process.

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Efficacy and safety of moxibustion on cancer-related fatigue: a systematic review and meta-analysis of randomized controlled trials

Cited by 2 publications

References 32 publications

Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

Assessment of Quality of Reporting in Randomized Controlled Trials of Moxibustion for Chronic Diseases Using the Consolidated Standards of Reporting Trials and Standards for Reporting Interventions in Clinical Trials of Moxibustion Statements

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