Efficacy and safety of methylphenidate in treating ADHD symptoms in children and adolescents with uncontrolled seizures: A Brazilian sample study and literature review

Koneski, Julio A.S.; Casella, Erasmo Barbante; Agertt, Fábio; Ferreira, Maria Gabriela

doi:10.1016/j.yebeh.2011.02.029

Cited by 40 publications

(31 citation statements)

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“…ADHD studies in epilepsy samples usually detect more inattentive subtype than in developmental ADHD [7], [9], [53], [54]. Finally, ADHD symptoms in children with epilepsy have been reported to improve with stimulant medication in in the same way they do in the general population [54]–[57].…”

Section: Discussionmentioning

confidence: 99%

Brain Morphology in Children with Epilepsy and ADHD

et al. 2014

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BackgroundAttention deficit hyperactivity disorder (ADHD) is a common comorbidity of childhood epilepsy, but the neuroanatomical correlates of ADHD in epilepsy have yet to be comprehensively characterized.MethodsChildren with new and recent-onset epilepsy with (n = 18) and without (n = 36) ADHD, and healthy controls (n = 46) underwent high resolution MRI. Measures of cortical morphology (thickness, area, volume, curvature) and subcortical and cerebellar volumes were compared between the groups using the program FreeSurfer 5.1.ResultsCompared to the control group, children with epilepsy and ADHD exhibited diffuse bilateral thinning in the frontal, parietal and temporal lobes, with volume reductions in the brainstem and subcortical structures (bilateral caudate, left thalamus, right hippocampus). There were very few group differences across measures of cortical volume, area or curvature.ConclusionsChildren with epilepsy and comorbid ADHD exhibited a pattern of bilateral and widespread decreased cortical thickness as well as decreased volume of subcortical structures and brainstem. These anatomic abnormalities were evident early in the course of epilepsy suggesting the presence of antecedent neurodevelopmental changes, the course of which remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Brain Morphology in Children with Epilepsy and ADHD

et al. 2014

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“…In this study a subgroup of 15 nonepileptic patients had epileptiform EEG at baseline and none of them had a seizure during the study period of 1 year. Several short term studies have reported that MPH is safe to use in both ADHD children with well controlled [25][26][27], and difficult to treat epilepsy [28][29][30], and that 61-73% of children with epilepsy had benefit from MPH. One study reported that use of combination of a behavioral management and MPH 0.3-1 mg/kg/day for 3 months improved ADHD symptoms in 61% of 18 patients with refractory epilepsy [29].…”

Section: Seizure Risk In Adhd Children With Ied and The Use Of Mph Anmentioning

confidence: 99%

Attention deficit/hyperactivity disorder and interictal epileptiform discharges: It is safe to use methylphenidate?

Socanski

Aurlien

Herigstad

et al. 2015

Seizure

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“…This is also reflected in the labeling of stimulant medications. A recent open label study by Koneski and colleagues has reported that methylphenidate is effective in treating ADHD and associated with a low seizure risk in patients with uncontrolled epilepsy (Koneski, Casella, Agertt, & Ferreira, 2011). They evaluated 24 patients aged 7 to 16 years old who had a diagnosis of ADHD and had at least two epileptic seizures in the previous 6 months and were on methylphenidate treatment for 6 months (Koneski et al, 2011).…”

Section: Seizuresmentioning

confidence: 99%

“…A recent open label study by Koneski and colleagues has reported that methylphenidate is effective in treating ADHD and associated with a low seizure risk in patients with uncontrolled epilepsy (Koneski, Casella, Agertt, & Ferreira, 2011). They evaluated 24 patients aged 7 to 16 years old who had a diagnosis of ADHD and had at least two epileptic seizures in the previous 6 months and were on methylphenidate treatment for 6 months (Koneski et al, 2011). They found that there was an overall improvement in ADHD symptoms in 70.8% with no increase in frequency of epileptic seizures in 22 patients (91.6%) (Koneski et al, 2011).…”

Section: Seizuresmentioning

confidence: 99%

“…They evaluated 24 patients aged 7 to 16 years old who had a diagnosis of ADHD and had at least two epileptic seizures in the previous 6 months and were on methylphenidate treatment for 6 months (Koneski et al, 2011). They found that there was an overall improvement in ADHD symptoms in 70.8% with no increase in frequency of epileptic seizures in 22 patients (91.6%) (Koneski et al, 2011). Another open label study by Santos and colleagues in a more severe epileptic population also showed that low dose methylphenidate was safe and effective in treating ADHD symptoms (Santos, Palmini, Radziuk, Rotert, Bastos, Booij et al, 2013).…”

Section: Seizuresmentioning

confidence: 99%

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