Efficacy and safety of mefloquine, artesunate, mefloquine–artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial

Soukhathammavong, Phonepasong Ayé; Odermatt, Peter; Sayasone, Somphou; Vonghachack, Youthanavanh; Vounatsou, Penelope; Hatz, Christoph; Akkhavong, Kongsap; Keiser, Jennifer

doi:10.1016/s1473-3099(10)70250-4

Cited by 80 publications

(53 citation statements)

References 28 publications

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“…Slides were read within 30 -45 min after preparation. Ten per cent of all smears were re-examined for quality control (Soukhathammavong et al, 2011). An O. viverrini-positive patient was defined as one with at least one O. viverrini egg present in at least one of the four Kato-Katz faecal thick smears.…”

Section: Laboratory Analysis Of Stool and Bloodmentioning

confidence: 99%

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

et al. 2015

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Evidence of severe hepatobiliary morbidity associated with Opisthorchis viverrini liver fluke infection including cholangiocarcinoma (CCA) is scarce in Laos although O. viverrini infection is highly prevalent. We assessed hepatobiliary morbidity using abdominal ultrasonography (US) in O. viverrini adult patients in Saravan province, Southern Laos. A random sample of 431 O. viverrini patients from 10 villages underwent abdominal US. Mild, moderate and markedly advanced periductal fibrosis was diagnosed in 7.0%, 66.5%, and 17.0% of patients, respectively. Normal liver parenchyma was seen in only 9.5% of patients. Presence of gall stones (13.2%), sludge (1.4%), gall wall thickening (1.2%), bile duct dilatation (1.6%), fatty liver (12.0%), kidney stones (8.6%) and cysts (7.9%) were diagnosed in considerable frequencies. In five patients (1.2%) hepatobiliary lesions suggesting CCA were diagnosed. Tumour markers, i.e. Interleukin-6, plasminogen activator inhibitor and carbohydrate antigen 19-9 were within normal range. The number of CCA suspected liver masses and hepatobiliary morbidity diagnosed among clinically asymptomatic adult patients in O. viverrini endemic areas presents a major public health concern in Laos. However, definitive diagnosis Opisthorchis-related severe sequelae including CCA is urgently needed to gauge the burden of this deadly disease in Laos.

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Section: Laboratory Analysis Of Stool and Bloodmentioning

confidence: 99%

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

et al. 2015

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“…The anthelmintic, praziquantel, has been more widely used than any other drug for treatment of OV infection because of its apparent effectiveness and the short time for the healing of damage done by OV following its eradication (Boonmars et al, 2007). However, while praziqantel seems effective against an existing infection with cure rates reported to be as high as 96% and 100% (Soukhathammavong et al, 2011), there is no evidence of any protective immunity against re-infection (Sirisinha et al, 1983;Upatham et al, 1988) and repeated dosing with the anthelmintic is necessary for those re-exposed to infection.…”

Section: Infection With Opisthorchis Viverrini and Use Of Praziquantementioning

confidence: 99%

Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand

Saengsawang

Promthet²,

Bradshaw³

2013

Asian Pacific Journal of Cancer Prevention

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Infection with Opisthorchis viverrini (OV) due to eating certain traditional freshwater fish dishes is the principal risk factor for cholangiocarcinoma in Northeast Thailand where the infection is endemic and the incidence of this form of primary liver cancer has been the highest in the world. This paper is the second report of a prospective research project to monitor the impacts of a national liver fluke control programme in a rural community of Northeast Thailand. A sample of 684 villagers aged 20-65 years completed an interview questionnaire and were tested for infection using the Kato thick smear technique. The questionnaire was designed for the exploration of associations between OV infection, previous treatment with praziquantel, and knowledge and beliefs about the drug. The data were analysed using descriptive statistics and multiple logistic regression. The overall prevalence of OV infection was 37.2% and was highest in the 20-35 year age group, in those with a university degree and in those employed in the government sector. As many as 91.8% reported eating fish dishes known to place them at risk of infection. In the multiple regression analysis, previous use of praziquantel and lack of knowledge about whether or not the drug has a protective effect against re-infection were the only factors related to OV infection (OR adj = 2.31, 95%CI =1.40-3.79 and OR adj = 1.95, 95%CI= 1.24-3.05). The findings were discussed in terms of the possibly unwise dependency on praziquantel as a primary element in a control programme.

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“…In the present intervention the individuals positive for O viverrini eggs were advised to take praziquantel, a very effective anti-helminthic drug (Soukhathammavong et al, 2011;Lovis et al, 2012), although it is unwise to depend on praziquantel as a primary element in a control programme as stressed earlier (Saengsawang et al, 2013). This has important implications in terms of evaluation of the efficacy of our present program since a simple comparison of before and after infection rates would not have meaning until the period typical for reinfection to occur has passed, which might stretch to many years.…”

Section: Community-based Interventions In Thailandmentioning

confidence: 99%

Development of a Community-Based Approach to Opisthorchiasis Control

Duangsong

Promthet²,

Thaewnongiew³

2013

Asian Pacific Journal of Cancer Prevention

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A liver fluke, Opisthorchis viverrrini (OV), is the major cause of the high incidence of cholangiocarcinoma in North-eastern Thailand. The prevalence of OV infection remains high in various parts of the country, especially in wetland rural areas where a large proportion of the community work in agriculture and continue the traditional practice of eating raw or uncooked cyprinoid fish products. The national control program seems to have had little impact in many of these areas, and it has been difficult to make precise assessments of the overall effectiveness of the program. Therefore there is a need for a community-based approach to prevent infection with the parasite, ideally involving as many players as possible. Here we document an attempt to assess the best means to prevention on the basis of a community intervention in three villages in north-east Thailand, with participation of representatives of Health Promotion Hospitals of the Ministry of Public Health with dedicated staff, but also school teachers, independent government sponsored village health volunteers, and housewives responsible for cooking and diet selection. An action plan was followed, allowing detailed discussions of practical proposals, their introduction and then repeated reflection and further proposals at the individual village level.

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Efficacy and safety of mefloquine, artesunate, mefloquine–artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial

Abstract: Swiss National Science Foundation, University of Basel.

Cited by 80 publications

References 28 publications

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

Subtle to severe hepatobiliary morbidity in Opisthorchis viverrini endemic settings in southern Laos

Infection with Opisthorchis viverrini and Use of Praziquantel among a Working-age Population in Northeast Thailand

Development of a Community-Based Approach to Opisthorchiasis Control

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