Efficacy and Safety of Mavacamten in the Treatment of Hypertrophic Cardiomyopathy: A Systematic Review

Bishev, Daniel; Fabara, Stephanie P; Loseke, Isaac; Alok, Akankcha; Al-Ani, Hashim; Bazikian, Yvette

doi:10.1016/j.hlc.2023.05.019

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…It works by reducing the activation of myosin heads on actin, which lowers adenosine triphosphate (ATP) turnover and LVOT obstruction, irrespective of genetic mutations, with the goal of avoiding surgery. 2 Beta-blockers (BB), on the other hand, lead to a decrease in maximum myocardial contraction velocity. This effect can potentially alter the degree of systolic anterior movement and subsequently affect the magnitude of LVOT obstruction in patients with HCM.…”

Section: Patients With Hypertrophic Cardiomyopathy: a Meta-analysis O...mentioning

confidence: 99%

“…1 According to a series of high-quality evidence, chemotherapy, immune checkpoint inhibitors, tyrosine kinase inhibitors (TKI), cytokine inhibitors, and corticosteroids significantly increase the risk of HBV reactivation, associated with poor prognosis and efficacy. 2 Therefore, it is necessary to screen for HBV. Clinically, we screen HBV infection through several serological markers: hepatitis B surface antigen…”

Section: Introductionmentioning

confidence: 99%

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Effects of Mavacamten Concomitant With Beta-Blockers on Patients With Hypertrophic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials

Rehan,

Ali,

Imran

et al. 2024

American Journal of Therapeutics

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Section: Patients With Hypertrophic Cardiomyopathy: a Meta-analysis O...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Mavacamten Concomitant With Beta-Blockers on Patients With Hypertrophic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials

Rehan,

Ali,

Imran

et al. 2024

American Journal of Therapeutics

View full text Add to dashboard Cite

Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review

Gill,

Siddiqui,

Yee

et al. 2024

JCDD

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Hypertrophic cardiomyopathy (HCM) is characterized by excessive growth of myocardial tissue, most commonly due to genetic mutations in sarcomere proteins. This can lead to complications such as heart failure, mitral regurgitation, syncope, arrhythmias, sudden cardiac death, and myocardial ischemia. While we have come a long way in our understanding of the pathophysiology, genetics, and epidemiology of HCM, the past 10 years have seen significant advancements in diagnosis and treatment. As the body of evidence on hypertrophic cardiomyopathy continues to grow, a comprehensive review of the current literature is an invaluable resource in organizing this knowledge. By doing so, the vast progress that has been made thus far will be widely available to all experts in the field. This review provides a comprehensive analysis of the scientific literature, exploring both well-established and cutting-edge diagnostic and therapeutic options. It also presents a unique perspective by incorporating topics such as exercise testing, genetic testing, radiofrequency ablation, risk stratification, and symptomatic management in non-obstructive HCM. Lastly, this review highlights areas where current and future research is at the forefront of innovation in hypertrophic cardiomyopathy.

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Efficacy and Safety of Mavacamten in the Treatment of Hypertrophic Cardiomyopathy: A Systematic Review

Cited by 2 publications

References 11 publications

Effects of Mavacamten Concomitant With Beta-Blockers on Patients With Hypertrophic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials

Effects of Mavacamten Concomitant With Beta-Blockers on Patients With Hypertrophic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials

Advancements in the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Comprehensive Review

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