Efficacy and safety of long-term, once-daily morphine sulfate extended-release capsules in cancer patients with chronic, moderate-to-severe pain

Opioid Analgesics in Primary Care: Challenges and New Advances in the Management of Noncancer Pain

“…78 In an openlabel trial, effectiveness and good tolerability was reported in cancer patients, and a randomized controlled trial reported improved quality of sleep compared with twice-daily morphine. 79,80 An ER liposome injection of morphine sulfate is now available for single-dose administration by the epidural route, at the lumbar level, for the treatment of pain following major surgery. This formulation uses DepoFoam technology to provide extended drug release from a liposomal depot after a single-dose injection.…”