Efficacy and Safety of Local Steroids for Urethra Strictures: A Systematic Review and Meta-Analysis

Zhang, Kaile; Qi, Er; Zhang, Yumeng; Yang, Sa; Fu, Qiang

doi:10.1089/end.2014.0090

Cited by 34 publications

(37 citation statements)

References 20 publications

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“…A double-blind, placebo controlled randomized trial of anterior urethral strictures undergoing DVIU compared triamcinolone with sterile water, however while there was a delay in stricture recurrence of 4–5 months, there was no significant difference in overall rates of stricture recurrence (51), consistent with a meta-analysis of steroids as an adjunct to internal urethrotomy (52). Mazdak et al undertook two prospective randomized controlled trials to determine if internal urethrotomy for anterior urethral strictures with submucosal injection of triamcinolone (45) or MMC (47) was more effective than internal urethrotomy alone.…”

Section: Managementmentioning

confidence: 67%

Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer

Nicholson

Al-Hakeem

Maldonado

et al. 2017

Transl. Androl. Urol.

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The aim of this review is to examine all urethral strictures and stenoses subsequent to treatment for prostate cancer, including radical prostatectomy (RP), radiotherapy, high intensity focused ultrasound (HIFU) and cryotherapy. The overall majority respond to endoscopic treatment, including dilatation, direct visual internal urethrotomy (DVIU) or bladder neck incision (BNI). There are adjunct treatments to endoscopic management, including injections of corticosteroids and mitomycin C (MMC) and urethral stents, which remain controversial and are not currently mainstay of treatment. Recalcitrant strictures are most commonly managed with urethroplasty, while recalcitrant stenosis is relatively rare yet almost always associated with bothersome urinary incontinence, requiring bladder neck reconstruction and subsequent artificial urinary sphincter (AUS) implantation, or urinary diversion for the devastated outlet.

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Section: Managementmentioning

confidence: 67%

Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer

Nicholson

Al-Hakeem

Maldonado

et al. 2017

Transl. Androl. Urol.

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“…[8] On that basis; Sciarra et al [9] used antiinflammatory drugs to reduce urethral strictures after TURP and suggested that COX-2 inhibitors can prevent development of post TURP urethral stricture. Yet, based on the same logic, several adjuvant therapies including colchicine [10] , mitomycin-c [11] , triamcinolone [12] , and corticosteroids [13] , which all have anti-inflammatory effects, have been used to treat urethral strictures either systematically or locally.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate

Gül¹,

Altintas²,

Kaynar³

et al. 2017

Turkish Journal of Urology

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Objective: The pathology of urethral stricture disease is still unclear however progressive inflammation may contribute to the development of urethral stricture. The platelet-to-lymphocyte ratio (PLR) is a new and simple marker that indicates inflammation. In this study we aimed to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and PLR in patients with urethral stricture who underwent transurethral resection of prostate (TURP). Material and methods:A total of 208 patients who underwent bipolar-TURP were included in this study. Patients who had previously undergone surgery due to any urethral pathology, posterior urethral strictures, previous or ongoing treatment for any cancer, hematologic disorders, presence of an active infection at the time of surgical intervention, and prior blood transfusion were excluded. PLR, NLR and red cell distribution width (RDW) levels were measured. In order to investigate the predictive values of NLR and PLR variables, binary logistic regression analysis was performed. Results:No statistically significant differences were observed between the groups in terms of age, NLR, RDW, prostate size and operative times. Statistically significant differences were presented only in the median PLR-values. For predicting urethral stricture, the optimal cut-off value was 112.5, (sensitivity: 0.84, specificity: 0.64; AUC= 0.762, 95% CI 0.684-0.84). Conclusion:In this study we showed that PLR can be used to determine urethral stricture as a cost-effective, common, and simple biomarker in patients after TURP.Keywords: Inflammation; neutrophil to lymphocyte ratio; platelet to lymphocyte ratio; urethral stricture.Cite this article as: Gül M, Altıntaş E, Kaynar M, Buğday MS, Göktaş S. The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate. Turk J Urol 2017; 43: 325-9

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“…Therefore, experimental and clinical studies have been performed to explore the efficacies of different molecules for preventing US formation. [20][21][22] Metalloproteinase-1 is another agent that has been used in an attempt to alleviate US after urethral injury. In one study, metalloproteinase-1 reportedly induced a lower collagen concentration in the traumatized region of the experimental group than the control group, and the researchers concluded that it contributed to the maintenance of urethral patency.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model

Üyetürk

Gücük²,

Fırat³

et al. 2014

Journal of Endourology

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Efficacy and Safety of Local Steroids for Urethra Strictures: A Systematic Review and Meta-Analysis

Cited by 34 publications

References 20 publications

Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer

Management of bladder neck stenosis and urethral stricture and stenosis following treatment for prostate cancer

The predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratio in determining urethral stricture after transurethral resection of prostate

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model

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