Efficacy and Safety of Lidocaine Patch in the Management of Acute Postoperative Wound Pain: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials

Shi, Wei; Ren, Yifeng; Chen, Jianfeng; Ye, Xin

doi:10.1089/wound.2022.0076

Cited by 1 publication

(2 citation statements)

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“…Koo and colleagues observed morphine consumption at 24 hours and 48 hours after surgery, whereas we assessed the total cumulative amount of morphine used after surgery, so there were differences between the studies. Another new meta-analysis, including 12 trials, showed that the LP group had lower cumulative intravenous morphine equivalent consumption than the placebo group, and LP alleviated dynamic and rest pain at 6-, 12-,24-, and 72-hour time points 33 . However, Shi and colleagues thought LP did not exceed the threshold for clinical significance.…”

Section: Discussionmentioning

confidence: 99%

“…Another new meta-analysis, including 12 trials, showed that the LP group had lower cumulative intravenous morphine equivalent consumption than the placebo group, and LP alleviated dynamic and rest pain at 6-, 12-,24-, and 72-hour time points. 33 However, Shi and colleagues thought LP did not exceed the threshold for clinical significance. Our thoughts disagree with theirs, and we believe the difference was small but still beneficial, especially for those patients’ intolerant of opioids.…”

Section: Discussionmentioning

confidence: 99%

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Is Lidocaine Patch Beneficial for Postoperative Pain?

Wu¹,

Wei

et al. 2023

The Clinical Journal of Pain

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Objectives: The aim of this meta-analysis was to evaluate whether a lidocaine patch is beneficial for postoperative pain as an option for multimodal analgesia. Methods: Information was obtained from PubMed, Embase, and the Cochrane Central Register of Controlled Trials for clinical randomized controlled trials of lidocaine patches for postoperative pain (as of March 2022). Two researchers independently completed study screening, risk bias assessment, and data extraction. Review Manager (version 5.4, Cochrane Collaboration) was used to conduct the meta-analysis. The evaluation metrics were postoperative pain scores, opioid consumption, and patient satisfaction. Results: Sixteen randomized controlled trials were included, and data from 918 patients were available. Pain scores differed between the 2 groups at 12, 24, and 48 hours postoperatively, and the pain scores of the lidocaine patch group were significantly lower (mean difference [MD]=−1.32 [95% CI, −1.96 to −0.68], P<0.0001; I 2=92%) at 12 hours after the operation; (MD=−1.23 [95% CI, −1.72 to −0.75], P<0.00001; I 2=92%) at 24 hours after the operation; and (MD=−0.25 [95% CI,−0.29 to −0.21], P<0.00001; I 2=98%) at 48 hours after the operation. In addition, the lidocaine patch group had decreased opioid requirements (MD=−3.57 [95% CI, −5.06 to −2.09], P<0.00001; I 2=96%). The lidocaine patch group seemed to be more satisfied, but there was no statistically significant difference (risk ratio, 1.50 [95% CI, 0.74 to 3.05], P=0.26) between the groups. Discussion: Lidocaine patches are beneficial for postoperative pain and can be used in multimodal analgesia to reduce opioid use, but there is no significant increase in patient satisfaction with pain control. More data are needed to support this conclusion due to the large heterogeneity in the present study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%