Efficacy and Safety of Lactobacillus plantarum DSM 9843 (LP299V) in the Prevention of Antibiotic-Associated Gastrointestinal Symptoms in Children—Randomized, Double-Blind, Placebo-Controlled Study

Olek, Agnieszka; Woynarowski, Marek; Ahrén, Irini Lazou; Kierkuś, Jarosław; Socha, Piotr; Larsson, Niklas; Önning, Gunilla

doi:10.1016/j.jpeds.2017.03.047

Cited by 42 publications

(42 citation statements)

References 13 publications

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“…In contrast, negative results have been found in other studies and meta-analyses regarding the effectiveness of probiotics in diarrhea prevention in children [214], adults [215] and the elderly [216,217]. A consistent and sufficient probiotic consumption might produce a number of health benefits including reducing CVD risk factors [201], nevertheless, further studies in different models are necessary for a better understanding of the beneficial mechanisms of probiotic administration in CVD risk alone or accompanied by foods; certainly, probiotics act in a strain-specific manner and are often used as coadjuvant therapy.…”

Section: Probiotic Administration Microbiota Bile Acids and Cardiovmentioning

confidence: 80%

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

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The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.

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Section: Probiotic Administration Microbiota Bile Acids and Cardiovmentioning

confidence: 80%

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

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“…Probiotics have been proposed to constitute an effective preventive treatment for antibiotics-induced dysbiosis and associated adverse effects in mice (Ekmekciu et al, 2017) and in some (Hempel et al, 2012) but not all human studies (Olek et al, 2017, Allen et al, 2013. Importantly, adverse effects associated with probiotics consumption may be under-reported in clinical trials (Bafeta et al, 2018), further complicating the efficacy debate.…”

Section: Introductionmentioning

confidence: 99%

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Suez

Zmora

Zilberman-Schapira

et al. 2018

Cell

807

590

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Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and related adverse effects. However, probiotic impact on post-antibiotic reconstitution of the gut mucosal host-microbiome niche remains elusive. We invasively examined the effects of multi-strain probiotics or autologous fecal microbiome transplantation (aFMT) on post-antibiotic reconstitution of the murine and human mucosal microbiome niche. Contrary to homeostasis, antibiotic perturbation enhanced probiotics colonization in the human mucosa but only mildly improved colonization in mice. Compared to spontaneous post-antibiotic recovery, probiotics induced a markedly delayed and persistently incomplete indigenous stool/mucosal microbiome reconstitution and host transcriptome recovery toward homeostatic configuration, while aFMT induced a rapid and near-complete recovery within days of administration. In vitro, Lactobacillus-secreted soluble factors contributed to probiotics-induced microbiome inhibition. Collectively, potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery, highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host.

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“…It is well known that non-hemolytic bacteria are part of the microorganism group Generally Recorganized as Safe (GRAS), which is the case of LAB. Lactobacilli strains do not pose a health risk to animals or humans (Rychen et al, 2017;Olek et al, 2017;Chaves et al, 2017).…”

Section: Hemolytic Activitymentioning

confidence: 99%

Selection of Lactobacillus strains newly isolated from Algerian camel and mare fermented milk for their in vitro probiotic and lipolytic potentials

Amara¹,

Zadi‐Karam²,

Karam³

2019

Afr. J. Biotechnol.

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The main objective of this study was the characterization of new lactobacilli probiotic strains belonging to lactic acid bacteria (LAB). Eighty-eight strains were isolated from different Algerian camel and mare fermented milks; three of them were pre-selected for their stability, fast growth and resistance to acidity and bile salts. Cell viability was assessed in simulated gastric and intestinal conditions. On the other hand, cell safety was checked by testing their hemolytic capacity. The in vitro tests revealed a good probiotic potential of selected strains. The majority of lactobacilli is resistant to cross-stress and persists beyond 4 h of incubation in contact with simulated gastrointestinal juices; a survival rate of over 80% was observed. All strains showed better lipolytic activity in the presence of natural substrates compared to Tween-80. Lipolysis zones diameters obtained in the presence of butter and olive oil were remarkable (between 20 and 27 mm respectively). Investigation of the cholesterol-lowering and the triglyceride-lowering properties revealed a cholesterol ratio degradation of 54.8% and a triglyceride ratio degradation of 80.3% for Lactobacillus plantarum NSC5C.

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Efficacy and Safety of Lactobacillus plantarum DSM 9843 (LP299V) in the Prevention of Antibiotic-Associated Gastrointestinal Symptoms in Children—Randomized, Double-Blind, Placebo-Controlled Study

Cited by 42 publications

References 13 publications

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

Selection of Lactobacillus strains newly isolated from Algerian camel and mare fermented milk for their in vitro probiotic and lipolytic potentials

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