Efficacy and safety of Kanglaite injection for gastric cancer

Hou, Daorui; Xiong, Jian; Xiong, Lei

doi:10.1097/md.0000000000021619

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Dodecanoic acid, tetradecanoic acid, 2,3-dihydroxypropylester, 1,3-dioctanoin, N -methoxy- N -methyl -3,4-dihydro-2 H -thiopyran6-carboxamide, 5-Amino-1-(quinolin-8-yl)-1,2,3-triazole-4- carboxamide, propanamide, and pyridine have been identified in adlay seeds oil [ 119 ]. Kanglaite injection from adlay seeds extracted is an NF-κΒ inhibitor that has been widely used for gastric cancer and advanced lung cancer [ 155 , 156 ]. Kanglaite pretreatment can not only increase the effect of taxol on colorectal cancer and cisplatin on HepG2 cells by inhibiting the CKLF1-mediated NF-κB pathway [ 157 , 158 ], but also inhibits tumor necrosis factor-alpha-mediated epithelial mesenchymal transition in colorectal cancer cell lines by inhibiting NF-κΒ [ 47 ].…”

Section: The Food and Pharmaceutical Industrymentioning

confidence: 99%

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Zeng

Yang²,

Chen

et al. 2022

Molecules

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Medicinal and food homologous adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) plays an important role in natural products promoting human health. We demonstrated the systematic actional mechanism of functional ingredients in adlay to promote human health, based on the PubMed, CNKI, Google, and ISI Web of Science databases from 1988 to 2022. Adlay and its extracts are rich in 30 ingredients with more than 20 health effects based on human and animal or cell cultures: they are anti-cancer, anti-inflammation, anti-obesity, liver protective, anti-virus, gastroprotective, cardiovascular protective, anti-hypertension, heart disease preventive, melanogenesis inhibiting, anti-allergy, endocrine regulating, anti-diabetes, anti-cachexia, osteoporosis preventive, analgesic, neuroprotecting, suitable for the treatment of gout arthritis, life extending, anti-fungi, and detoxifying effects. Function components with anti-oxidants are rich in adlay. These results support the notion that adlay seeds may be one of the best functional foods and further reveal the action mechanism of six major functional ingredients (oils, polysaccharides, phenols, phytosterols, coixol, and resistant starch) for combating diseases. This review paper not only reveals the action mechanisms of adding adlay to the diet to overcome 17 human diseases, but also provides a scientific basis for the development of functional foods and drugs for the treatment of human diseases.

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Section: The Food and Pharmaceutical Industrymentioning

confidence: 99%

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Zeng

Yang²,

Chen

et al. 2022

Molecules

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show abstract

“…The ethanolic extracts of Coix seed, a famous Chinese traditional herb, reportedly remarkably inhibit the viability of GC AGS cells [ 9 ]. Furthermore, injection of kanglaite, an ingredient extracted from Coix seed, has been clinically utilized as a broad-spectrum antitumor drug against GC [ 15 ]. L. edodes extracts, such as Latcripin 1, can effectively induce apoptosis and suppress metastasis in SGC-7901 and BGC-823 human GC cells [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial–mesenchymal transition via the canonical Wnt/β-catenin signaling pathway

Chen

Yue

Tian

et al. 2021

BMC Complement Med Ther

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Background Natural products, especially those with high contents of phytochemicals, are promising alternative medicines owing to their antitumor properties and few side effects. In this study, the effects of a plant-based medicinal food (PBMF) composed of six medicinal and edible plants, namely, Coix seed, Lentinula edodes, Asparagus officinalis L., Houttuynia cordata, Dandelion, and Grifola frondosa, on gastric cancer and the underlying molecular mechanisms were investigated in vivo. Methods A subcutaneous xenograft model of gastric cancer was successfully established in nude mice inoculated with SGC-7901 cells. The tumor-bearing mice were separately underwent with particular diets supplemented with three doses of PBMF (43.22, 86.44, and 172.88 g/kg diet) for 30 days. Tumor volumes were recorded. Histopathological changes in and apoptosis of the xenografts were evaluated by hematoxylin and eosin staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, respectively. Serum levels of TNF-α, MMP-2, and MMP-9 were detected by enzyme-linked immunosorbent assay. The mRNA expression levels of β-catenin, GSK-3β, E-cadherin, N-cadherin, MMP-2/9, Snail, Bax, Bcl-2, Caspase-3/9, and Cyclin D1 were evaluated via real-time quantitative polymerase chain reaction. The protein expression levels of GSK-3β, E-cadherin, N-cadherin, and Ki-67 were determined by immunohistochemistry staining. Results PBMF treatment efficiently suppressed neoplastic growth, induced apoptosis, and aggravated necrosis in the xenografts of SGC-7901 cells. PBMF treatment significantly decreased the serum levels of MMP-2 and MMP-9 and significantly increased that of TNF-α. Furthermore, PBMF treatment notably upregulated the mRNA expression levels of GSK-3β, E-cadherin, Bax, Caspase-3, and Caspase-9 but substantially downregulated those of β-catenin, N-cadherin, MMP-2, MMP-9, Snail, and Cyclin D1 in tumor tissues. The Bax/Bcl-2 ratio was upregulated at the mRNA level. Moreover, PBMF treatment remarkably increased the protein expression levels of GSK-3β and E-cadherin but notably reduced those of Ki-67 and N-cadherin in tumor tissues. Conclusions The PBMF concocted herein exerts anti-gastric cancer activities via epithelial–mesenchymal transition reversal, apoptosis induction, and proliferation inhibition. The underlying molecular mechanisms likely rely on suppressing the Wnt/β-catenin signaling pathway.

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Efficacy and safety of Kanglaite injection for gastric cancer

Cited by 2 publications

References 38 publications

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial–mesenchymal transition via the canonical Wnt/β-catenin signaling pathway

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