Abstract:<strong>Background </strong>High plasma
triglyceride (TG) is an independent risk factor for cardiovascular disease. Fibrates lower TG-levels through
PPARα agonism. Currently available fibrates, however, have relatively low
selectivity for PPARα.<b></b>
<p><strong>Objectives</strong> The aim of this
trial was to assess the safety, tolerability and efficacy of K-877
(pemafibrate) —a selective PPARα modulator —in statin-treated European
patients with hypertriglyceridemia… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.