Efficacy and Safety of Jollab to Treat Functional Dyspepsia: A Randomized Placebo–Controlled Clinical Trial

Pasalar, Mehdi; Choopani, Rasool; Mosaddegh, Mahmoud; Kamalinejad, Mohammad; Mohagheghzadeh, Abdolali; Fattahi, Mohammad Reza; Ghanizadeh, Ahmad; Lankarani, Kamran Bagheri

doi:10.1016/j.explore.2015.02.007

Cited by 31 publications

(38 citation statements)

References 47 publications

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“…The studies published between 1991 and 2019 were included. Patients had FD, [15][16][17][18][19][20][21][22]13,14,[23][24][25][26][27][28][29][30][31][32] and constipation [56][57][58][59][60][61][62] in 19, 23 and 7 trials respectively. More than 33 different kinds of herbal formulae were tested in the included trials.…”

Section: Resultsmentioning

confidence: 99%

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Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

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Background and Aims The efficacy of herbal medicines (HMs) for functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional dyspepsia (FD) and functional constipation (FC) is controversial. A systematic review with meta‐analysis was conducted to determine their effectiveness for FGIDs. Methods We searched the following electronic databases till July 2019 with English language restriction: The Cochrane Library, EMBASE and PUBMED. Randomized double‐blind controlled trials of HMs compared with placebo or conventional pharmacological drugs for adult FGIDs patients were included. Results In total, 49 trials involving 7396 participants with FGIDs were included. The risk of bias was low in 9, unclear in 36, and high in 4 trials. More than 33 different herbal formulae were tested. HMs demonstrated statistically significant benefits for symptom improvement compared with placebo in 46 trials (RR = 1.67, 95% CI 1.48–1.88). When compared with conventional pharmacological therapy in 5 trials, HMs were found to be non‐inferior (RR = 1.10, 95% CI 1.03–1.18). The number of trials with regards to FD, IBS and FC were 19, 23 and 7 respectively. Subgroup analysis found that HMs were better than placebo in alleviating symptoms for FD (RR = 1.50, 95% CI 1.32–1.69), IBS (RR = 1.62, 95% CI 1.32–1.97) and FC (RR = 3.83, 95% CI 2.26–6.50). HMs tended to have more patients with adverse events than placebo, but similar to conventional pharmacological drugs. Conclusions Our findings provide a positive signal for HMs as a potentially well‐tolerated and effective treatment for FGIDs, deserving further examination in high‐quality trials.

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Section: Resultsmentioning

confidence: 99%

“…Adverse events. Six trials 18,13,14,28,40,43,59 had reported serious adverse events (AEs) but the relationships to most of the experimental drugs were assessed by the investigators as unlikely. HMs tended to have more patients with AEs than placebo (RR = 1.22, 95% CI 1.06-1.41, Fig.…”

Section: Resultsmentioning

confidence: 99%

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Tan

Gwee

Tack

et al. 2019

J of Gastro and Hepatol

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“…143 More than 44 herbal preparations have been studied and reported to be of benefit in the treatment of FD. 144,145 Various studies have evaluated the efficacy of herbal extracts in the treatment of FD. In a recent metaanalysis of the herbal preparation STW5 (Iberogast; Steigerwald Arneimittelwerk GmbH, Darmstadt, Germany) it was found that, in comparison with placebo, patients receiving Iberogast enjoyed a significantly greater improvement in their symptoms after 4 weeks of treatment.…”

Section: Nonpharmacologic Therapiesmentioning

confidence: 99%

Definition, Pathogenesis, and Management of That Cursed Dyspepsia

Koduru

Irani

Quigley

2018

Clinical Gastroenterology and Hepatology

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Dyspepsia is an umbrella term used to encompass a number of symptoms thought to originate from the upper gastrointestinal tract. These symptoms are relatively nonspecific; not surprisingly, therefore, a myriad of conditions may present with any one or a combination of these symptoms. Therein lays the clinician's first challenge: detecting the minority who may have a potentially life-threatening disorder, such as gastric cancer, from a population whose symptoms are, for the most part, considered functional in origin. The second challenge lies in the definition and management of those individuals with functional dyspepsia (FD); the major focus of this review. The Rome process has addressed the issue of FD definition and a look back at the evolution of Rome criteria for this disorder illustrates the complexities that have so frustrated us. There has been no shortage of hypotheses to explain symptom pathogenesis in FD; initially focused on gastric sensorimotor dysfunction, these have now strayed well into the duodenum and have come to entertain such factors as immune responses and the microbiome. FD has proven to be an equally challenging area for therapeutics; while the staple approaches of acid suppression and eradication of Helicobacter pylori have some limited efficacy in select populations, strategies to ameliorate symptoms in the majority of sufferers based on presumed pathophysiology have largely foundered. Lacking a validated biomarker(s) FD continues to be an elusive target and is likely to remain so until we can better define the various phenotypes that it must surely contain.

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“…constipation, irritable bowel syndrome, and dyspepsia) and gynecological diseases (e.g. abnormal menstrual bleeding and infertility) (6)(7)(8)(9)(10). Patients' satisfaction with PM therapies was the focus of several studies.…”

Section: Introductionmentioning

confidence: 99%

Treatment Satisfaction with Persian Medicine in Patients with Insomnia

et al. 2019

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Background: Treatment satisfaction is a major contributor to treatment efficacy and its compliance in patients. Sleep disorders are among the common problems with insomnia as the epitome.Objectives: The current study aimed at assessing the degree to which patients with insomnia are satisfied with Persian medicine (PM) therapies. Methods:The current cross-sectional study was conducted in the PM Healthcare Clinic affiliated to Iran University of Medical Sciences in 2017. A total of 100 patients with insomnia signed written informed consent and completed the insomnia severity index (ISI) before and one month after receiving PM therapies. Moreover, patients completed the treatment satisfaction questionnaire after completion of the treatment course. The results were analyzed with SPSS software. Results:The ISI total score changed from 16.49 ± 3.87 to 12.53 ± 4.59 at the end of the study (P < 0.001). The score changed for all ISI items was statistically significant, except for the item "noticeability of sleep problems by others". It was found that 76% of the subjects were satisfied with the efficacy of the treatments, 71% expressed satisfaction with the convenience and appropriateness of treatments, 81% did not report any complications using PM therapies, and 91% had an overall satisfaction with the treatments.Conclusions: PM therapeutic procedures can be effective in treating insomnia. According to the patients' satisfaction with PM therapies for insomnia, it is suggested that the efficacy of these procedures be investigated through clinical trials.

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Efficacy and Safety of Jollab to Treat Functional Dyspepsia: A Randomized Placebo–Controlled Clinical Trial

Cited by 31 publications

References 47 publications

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Herbal medicine in the treatment of functional gastrointestinal disorders: A systematic review with meta‐analysis

Definition, Pathogenesis, and Management of That Cursed Dyspepsia

Treatment Satisfaction with Persian Medicine in Patients with Insomnia

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