2017
DOI: 10.1097/md.0000000000006940 View full text |Buy / Rent full text
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Abstract: Background:Patients undergoing hip fracture surgery frequently require blood transfusion. Tranexamic acid (TXA) has been widely used to decrease blood loss and transfusion rates in joint replacement surgery. Therefore, we conducted a meta-analysis to evaluate efficacy and safety of intravenous TXA administration in patients suffering from hip fractures.Methods:Electronic databases were searched before December 2016 by 2 independent reviewers, including Cochrane Library, EMBASE, PubMed, Web of Science, the Chin… Show more

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“…In our study, no statistically significant differences were found between the TXA and placebo groups for incidence of wound complications, thromboembolic events, or mortality after 6 months' follow-up (Table 3). Our results were in accordance with the systematic reviews of Farrow et al 38 and Zhang et al, 33 which indicated that TXA did not increase the risk of wound complications, thromboembolic events, or mortality.…”
Section: Discussionsupporting
“…These results are consistent with those of previous studies. 33,34 Gausden et al 35 and Schiavone et al 36 reported significant reductions in transfusion rates with TXA use versus placebo. In the TXA in Hip Fracture Surgery study, Zufferey et al 17 also reported the same trend with a 30% relative reduction in transfusion rates with TXA administration.…”
Section: Discussionmentioning
“…7 of the questions were considered high quality, between 4 and 7 were moderate quality, and "yes" for 4 questions were low quality. 27 Additionally, the quality assessment of the observational studies was performed with the methodological items for nonrandomized studies (MINORS) criteria, with the various questions scored on a scale of 0 to 2, where a score of 16 for noncomparative and 24 for comparative studies was considered to be ideal, or high quality. 28…”
Section: Quality Assessmentmentioning
“…[8,9] Studies have further employed this homeostatic nature of tranexamic acid to reduce blood loss and transfusion rates in patients with intertrochanteric fracture undergoing PFNA. [1013]…”
Section: Introductionmentioning
“…20 It is worthy of note that allogeneic blood transfusions are not free of risk, and are associated with disease transmission, hemolytic reaction, and cardiovascular dysfunction. 21 Previous bleeding episodes, especially those occurring during invasive procedures or trauma, are primary determinants in assessing surgical bleeding risk, as is the use of concomitant antiplatelet and nonsteroidal anti-inflammatory medications. 22 In elective orthopaedic surgery, NOACs are more effective than LMWHs for prevention of VTE (RR ranging from 0.71 for apixaban to 0.49 for edoxaban), but they are more likely to be associated with major bleeding episodes (increased RR: 1.27).…”
Section: Hemorrhagic Riskmentioning