Efficacy and safety of intravenous tocainide compared with intravenous lidocaine for acute ventricular arrhythmias immediately after cardiac surgery

Morganroth, Joel; Panidis, Ioannis P.; Harley, Sally; Johnson, Jeanne L.; Smith, Eric G.; MacVaugh, Horace

doi:10.1016/s0002-9149(84)80075-2

Cited by 21 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to analgesia studies, several have concluded AEs were either comparable to placebo or negligible. [22][23][24] Morganroth et al, 25 however, found AEs in 18% of patients with an 8% discontinuation rate, closer to the findings of our study. Rademaker et al 26 evaluated the use of intravenous lidocaine for prophylaxis following proven or suspected myocardial infarction.…”

Section: Discussionsupporting

confidence: 91%

Evaluating the Safety of Continuous Infusion Lidocaine for Postoperative Pain

Schuler

Lupi

Szumita

et al. 2021

The Clinical Journal of Pain

View full text Add to dashboard Cite

Objectives: The aim was to evaluate the safety of intravenous lidocaine for postoperative pain and the impact on opioid requirements and pain scores Materials and Methods: This was a single-center, retrospective, single-arm analysis of adult patients who received intravenous lidocaine for postoperative pain from January 2016 to December 2019. Patients were excluded if they received lidocaine for any indication other than pain or if lidocaine was only given intraoperatively. The primary outcome of this analysis was to determine the incidence of adverse effects (AEs) and the reason for discontinuation of lidocaine. Secondary outcomes included median daily pain scores (visual analog scale and Critical-Care Pain Observation Tool) and opioid consumption (daily morphine milligram equivalents) 24 hours before infusion and during day 1.Results: A total of 452 patients were evaluated of which 298 (65.9%) patients met inclusion criteria. Of the 154 patients excluded, 153 did not receive lidocaine postoperatively. The median duration of infusion was 34 [20:48] hours with a median initial and maintenance rate of 1 mg/kg/h dosed on ideal body weight. In our analysis, 174 (58.4%) patients had a documented AE during infusion and 38 (12.8%) had lidocaine discontinued because of an AE. The most common AE was nausea in 62 (20.8%) patients and the most common reason for discontinuation was confusion in 8 (2.7%) patients. Daily morphine milligram equivalents (P < 0.001) and visual analog scale (P < 0.001) significantly decreased when comparing 24 hours before infusion and day 1. Conclusion:Although a majority of patients receiving lidocaine for postoperative pain experienced an AE, this did not result in discontinuation in most patients.

show abstract

Section: Discussionsupporting

confidence: 91%

Evaluating the Safety of Continuous Infusion Lidocaine for Postoperative Pain

Schuler

Lupi

Szumita

et al. 2021

The Clinical Journal of Pain

View full text Add to dashboard Cite

show abstract

“…Results from the literature review on unwanted effects of i.v. lidocaine treatment in adults are presented in Table 2, including only case series (9, 10, 14–63). It includes 50 series and around 6000 patients treated for different reasons: surgical patients (for anaesthesia), pain and headache patients (for analgesia), cardiac patients (for ventricular arrhythmias), epileptic patients (for seizure control) and also healthy volunteers in experimental conditions.…”

Section: Resultsmentioning

confidence: 99%

Neuropsychiatric Side-Effects of Lidocaine: Examples from the Treatment of Headache and a Review

Gil‐Gouveia

Goadsby

2009

Cephalalgia

View full text Add to dashboard Cite

Lidocaine has been used in treatment of patients with refractory headache. Personal observations of neuropsychiatric toxicity in these patients led us to review our cases and the literature systematically for lidocaine side-effects, especially neuropsychiatric symptoms. In our series of 20 patients, side-effects were observed in all, the most frequent being neuropsychiatric (75%) and cardiological (50%). When reviewing published series on intravenous lidocaine use, reports of side-effects range from 0 to 100%, with neuropsychiatric symptoms being reported in 1.8-100%. Thirty-six case reports of lidocaine-induced psychiatric symptoms were also analysed. Psychiatric symptoms of toxicity were similar in most patients, despite their differing ages, pathologies, co-therapies and lidocaine dosages. In conclusion, lidocaine neuropsychiatric toxicity has a well-recognized stereotypical clinical presentation that is probably unrecognized in headache series. As lidocaine represents an emerging alternative therapy in headache, particularly in short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, clinicians and patients should be aware of the extent of this problem.

show abstract

“…Não obstante que a lidocaína seja considerada um fármaco relativamente seguro, a sua atividade no corpo humano depende fortemente da sua concentração. Ademais, o seu uso excessivo e duradouro pode provocar hipotensão arterial, a dita sensação de cabeça leve, ziziamento no ouvido e parestesias [23,24]. Outrossim, no caso do uso indevido ele pode causar excitação do sistema nervoso central (SNC), depressão e reação alérgica [25][26][27].…”

Section: Discussionunclassified

“…Ao rearranjarmos a inequação (23), com a eliminação dos elementos iguais com signos contrários, obter-se-á o requisito de estabilidade de forma ainda mais clara:…”

Section: Discussionunclassified

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada

Tkach

Ivanushko

Lukanova

et al. 2018

Rev. colomb. cienc. quim. farm.

View full text Add to dashboard Cite

ResumoO comportamento eletroquímico da lidocaína durante a sua eletrooxidação sobre o oxihidróxido de cobalto trivalente em meio levemente básico, realizada para fins eletroanalíticos, foi avaliado do ponto de vista mecanístico matemático. Da análise foi feita uma conclusão acerca do desempenho do CoO(OH) como modificador de elétrodo na eletrooxidação da lidocaína in vivo e in vitro. Foi, outrossim, verificada a possibilidade da realização das instabilidades oscilatória e monotônica no sistema.Palavras-chave: segurança de medicação, elétrodos quimicamente modificados, lidocaína, oxihidróxido de cobalto, estado estacionário estável. Summary Lidocaine CoO(OH)-assisted electrochemical determination. A theoretical possibility to be evaluatedThe electrochemical behavior of lidocaine during its electrooxidation over trivalent cobalt oxyhydroxide in lightly alkaline medium, realized for electroanalytical purposes, was evaluated from the mechanistic mathematical point of view. From Artigo de pesquisa científica / http: //dx.doi.org/10.15446/rcciquifa.v47n1.70659

show abstract

Efficacy and safety of intravenous tocainide compared with intravenous lidocaine for acute ventricular arrhythmias immediately after cardiac surgery

Cited by 21 publications

References 34 publications

Evaluating the Safety of Continuous Infusion Lidocaine for Postoperative Pain

Evaluating the Safety of Continuous Infusion Lidocaine for Postoperative Pain

Neuropsychiatric Side-Effects of Lidocaine: Examples from the Treatment of Headache and a Review

A detecção eletroquímica da lidocaína sobre o oxihidróxido de cobalto trivalente. Uma possibilidade teórica a ser avaliada

Contact Info

Product

Resources

About