Efficacy and Safety of Indigo Naturalis in Combination with Narrow-Band Ultraviolet B for Treatment of Pityriasis Rosea: A Meta-Analysis

Abstract

Pityriasis rosea (PR), a skin rash, causes substantial discomfort in patients. There is a lack of effective therapies for PR. A combination of ultraviolet irradiation and indigo naturalis treatment has been shown to be a safe and effective regime for control of PR; however, the data have been largely inconsistent. Tis meta-analysis further evaluated the efficacy and safety of this combination in patients with PR. The PubMed, Embase, Cochrane Library, CNKI, VIP, and Wan Fang databases were searched for relevant RCTs of this combination therapy in patients with PR. A total of eight studies with a combined study population of 688 patients published between January 2006 and March 2016 were eligible for this meta-analysis. The RevMan 5.3 software was used for the meta-analysis. The regimen of compound indigo naturalis plus NB-UVB showed much better control of PR as compared to that achieved with use of compound indigo naturalis or NB-UVB alone in terms of cure rate or effective rate. However, no significant difference was observed between the two with respect to incidence of adverse effects. The analysis was affected by publication bias as revealed by funnel plot analysis. Further studies with large sample sizes are required to confirm our findings.

Perbandingan Efektivitas Terapi Asiklovir dibandingkan dengan Plasebo pada Pitiriasis Rosea: Sebuah Laporan Kasus Berbasis Bukti

“…2 Lesi klasik dimulai dengan herald patch pada batang tubuh yan bertahan dalam 2-4 hari pada anak, dilanjutkan dengan erupsi sekunder pada bagian ekstremitas. 3 Tipe atipikal dapat tejadi secara unilateral, lokal, atau inversa yang mencakup 20% kasus, dan hanya terdapat sedikit laporan kasus mengenai tipe ini. 4 Meskipun kejadiannya cukup sering, mudah untuk didiagnosis, dan memerlukan waktu untuk penyembuhan tanpa pengobatan kurang lebih dalam 3 -8 minggu, dapat terjadi lesi atipik, persisten, luas, dan relaps pada penyakit ini.…”