Efficacy and Safety ofMorinda citrifoliaL. (Noni) as a Potential Anticancer Agent

Abstract

Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.

Unveiling coastal diversity: An inventory and conservation report of beach forest flora of Surigao del Sur, Philippines

“…M. citrifolia, also known as noni, is a tree or shrub in the Rubiaceae family with a pantropical distribution (Nelson 2003), which is abundant in the coastline of the province; and has found various beneficial effects due to its phytochemicals (Abou Assi et al 2017;Almeida et al 2019). Noni extracts have shown anticancer properties (Kumar et al 2022) and are not toxic or mutagenic, and have potential use in phytotherapeutic or nutritional contexts (de Matos Lima et al 2022).…”

Unveiling the potential of Muscadine grape Skin extract as an innovative therapeutic intervention in cancer treatment

“…Hence, exploring phytochemicals has led to the discovery of effective anticancer medications. Numerous plant species, such as the Azadirachta indica ( Moga et al, 2018 ) and Morinda citrifolia ( Chanthira Kumar et al, 2022 ), have shown the presence of anti-cancer capabilities in their respective floral components. Pomegranate ( Panth et al, 2017 ), brassinosteroids ( Panibrat et al, 2019 ), medicinal mushrooms ( De Silva et al, 2012 ), ginger extract ( de Lima et al, 2018 ), and turmeric extract ( Unlu et al, 2016 ), have been shown to possess qualities that might inhibit the growth and spread of cancer cells.…”

Morinda citrifolia L.(Noni)-A Review on its health benefits, Phytochemistry and its recent researches.

“…Vitamis (C, ascorbic acid, E, tocopherol etc.) are major non-enzymatic anti-oxidant that have main effects because of their free radical forage property [6].…”