Efficacy and Safety of High-dose Vitamin C on Complex Regional Pain Syndrome in Extremity Trauma and Surgery—Systematic Review and Meta-Analysis

Shibuya, Naohiro; Humphers, Jon M.; Agarwal, Monica R.; Jupiter, Daniel C.

doi:10.1053/j.jfas.2012.08.003

Cited by 89 publications

(55 citation statements)

References 46 publications

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“…Parenteral vitamin C also readily and rapidly reduces pain in patients with shingles [3,4] , likely through its neuromodulatory functions [20] . Recent studies have shown that high dose oral vitamin C acts as an analgesic for complex regional pain syndrome [21] , however, the patient reported no effects on her pain levels whilst consuming 1,000 mg/d oral vitamin C. Placebo injections were not carried out with this case, thus it is not possible to rule out a placebo effect. Nevertheless, it is likely that, due to the multiple in vivo functions of vitamin C, the parenteral vitamin C contributed to the observed reduction of fatigue and pain in this patient.…”

Section: Discussionmentioning

confidence: 72%

Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis

Carr

Vissers

Cook³

2015

CRCP

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Preliminary studies have shown parenteral vitamin C to be effective against cancer-related fatigue and herpes zoster-related pain. Our aim was to determine the effects of parenteral vitamin C on chronic fatigue and pain in a patient with multiple morbidities. Here we report on a case of a 47 year old female with rheumatoid arthritis and mononeuritis multiplex, secondary to CNS vasculitis, whose primary symptoms were chronic fatigue, pain and insomnia. Parenteral vitamin C (50 g/session) was administered to this patient and quality of life (EORTC QLQ-C30) and multidimensional fatigue (MFSI-SF) questionnaires were administered before and after treatment. The quality of life questionnaire showed a dramatic improvement in the patient's global health status, in particular, enhanced physical, role and cognitive functioning. Most notably, dramatic decreases were observed in the patient's primary symptoms of fatigue, pain and insomnia. The multidimensional fatigue questionnaire indicated decreases in general, physical, emotional and mental fatigue, as well as a doubling of vigour. No adverse events were reported by the patient or her physician following parenteral vitamin C administration. The use of parenteral vitamin C could be considered for the management of chronic fatigue and pain.

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Section: Discussionmentioning

confidence: 72%

Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis

Carr

Vissers

Cook³

2015

CRCP

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“…Some studies associated vitamin C intake (500 mg/day) after a limb trauma/surgery with a significant reduction in the development of CRPS, when compared to placebo [16], suggesting a dose of 500 mg daily for 50 days. Treatment and management typically involves medication for neuropathic pain (refer to topic above about chronic pain management and pregnancy).…”

Section: Complex Regional Pain Syndrome (Crps)mentioning

confidence: 99%

Complex regional pain syndrome and pregnancy

Campanharo¹,

Filho²,

Lara³

et al. 2017

Clin Obstet Gynecol Reprod Med

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A 37-year-old patient with Complex Regional Pain Syndrome(CRPS) and continuous intrathecal morphine administration presents to prenatal care pregnant with 16 weeks' gestation. Besides CRPS, she has other medical conditions like obesity, migraine and angina, using topiramate and diltiazem.The discussion goes through an overview of CRPS and chronic pain management in pregnancy. In the end, we include a summary and recommendations based on a brief review of the literature.

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“…de la vitamina C a dosis de 500 mg durante 50 días como prevención tras una cirugía o traumatismo en el pie y tobillo, reduciendo la incidencia de este temido síndrome, por el efecto teórico antioxidante del ácido ascórbico 44 .…”

Section: Figura 10unclassified

Fracturas de calcáneo: controversias y consensos

Herrera-Pérez

Gutiérrez-Morales

Valderrábano

et al. 2016

Revista del Pie y Tobillo

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Resumen El calcáneo es el hueso que más frecuentemente se fractura del tarso, el 75% de las fracturas son intraarticulares y su tratamiento sigue siendo hoy en día objeto de debate. Pretendemos en esta actualización destacar los puntos de controversia, así como clarificar los consensos, especialmente en el tratamiento de las fracturas intraarticulares, y describir el manejo de las principales complicaciones. © 2016 SEMCPT. Publicado por Elsevier España, S.L.U. Este es un artículo Open Access bajo la CC BY-NC-ND licencia (http://creativecommons.org/licencias/by-nc-nd/4.0/). Abstract Calcaneal fractures are the most common tarsal fractures, 75% of them considered as intra-articular. Definitive treatment remains today debated. We intend in this update to highlight the points of controversy and clarify the consensus, especially in the treatment of intra-articular fractures, and to describe the management of major complications.

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Efficacy and Safety of High-dose Vitamin C on Complex Regional Pain Syndrome in Extremity Trauma and Surgery—Systematic Review and Meta-Analysis

Cited by 89 publications

References 46 publications

Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis

Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis

Complex regional pain syndrome and pregnancy

Fracturas de calcáneo: controversias y consensos

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