Efficacy and Safety of High-Dose Propranolol for the Management of Infant Supraventricular Tachyarrhythmias

Barton, Andrea; Moffett, Brady S.; Valdés, Santiago O.; Miyake, Christina Y.; Kim, Jeffrey

doi:10.1016/j.jpeds.2014.08.067

Cited by 31 publications

(29 citation statements)

References 8 publications

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“…Barton et al reported the co-occurrence of CHD and SVT to be 20%. 11 We detected anatomical pathology in 20.2% of patients, and 25% of lesions were either VSD or ASD.…”

Section: Discussionmentioning

confidence: 77%

“…Adenosine should be the first‐line drug for SVT other than atrial flutter. In atrial flutter, cardioversion should be the first treatment option . In a study involving 2,848 infants with SVT, 48% ( n = 1,379) were given abortive therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of SVT concomitant with CHD has been reported in various series. 10,11 In a large multicenter study, the incidence of CHD was 13% (n = 367), and most commonly associated lesions were VSD (n = 142), atrial septal defect (ASD; n = 122), and Ebstein's anomaly (n = 10). Barton et al reported the co-occurrence of CHD and SVT to be 20%.…”

Section: Discussionmentioning

confidence: 99%

“…In atrial flutter, cardioversion should be the first treatment option. 11 In a study involving 2,848 infants with SVT, 48% (n = 1,379) were given abortive therapy. Adenosine was given in 90% of patients, and the remaining 10% received cardioversion.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Sustained tachyarrhythmia in children younger than 1 year of age: Six year single‐center experience

Şahin¹,

Öztürk²,

Kaşar³

et al. 2018

Pediatrics International

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“…Barton et al reported the co-occurrence of CHD and SVT to be 20%. 11 We detected anatomical pathology in 20.2% of patients, and 25% of lesions were either VSD or ASD.…”

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Sustained tachyarrhythmia in children younger than 1 year of age: Six year single‐center experience

Şahin¹,

Öztürk²,

Kaşar³

et al. 2018

Pediatrics International

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“…In 2015, in the Journal of Pediatrics, Andrea L. Barton et al published the article [13] about the efficacy and safety of high dosage propranolol for the treatment of supraventricular tachycardia in newborns. The research was held over 287 children with the average age of 17 days and with the average dose of 3.6 ± 1.0 mg/kg/ day.…”

Section: Abstract Background Tachyarrhythmia Is the Most Severe Rhymentioning

confidence: 99%

Тахиаритмия У Новорожденных. Клинический Случай Трепетания Предсердий У Новорожденного

Kuryliak¹,

Burak²,

Malska³

2021

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Актуальность. Тахиаритмии — это наиболее опасное нарушение ритма у новорожденных и детей грудного возраста. Редкой формой тахиаритмии, не характерной для новорожденных, является трепетание предсердий (ТП). ТП у новорожденных встречается с частотой 1 : 50 000 и составляет 3 % от всех нарушений ритма у новорожденных. Цель заключается в исследовании тахиаритмии новорожденных на примере клинического случая трепетания предсердий у новорожденного. Материалы и методы. В этой статье был рассмотрен клинический случай сложного нарушения ритма у новорожденного мальчика, а именно: трепетание предсердий 2 : 1, 3 : 1 с рецидивирующими приступами пароксизмальной наджелудочковой тахикардии, частыми желудочковыми экстрасистолами и пониженной сократимостью миокарда. Для исследования трепетания предсердий были использованы следующие методы: ЭКГ, 2D допплер-ЭхоКГ. Результаты. Медикаментозное лечение данного нарушения ритма состояло в следующем: АТФ в/в болюсно, повторно — неэффективно, инфузия кордарона 15 мг/кг/сут, седация. В связи с нарастанием сердечной недостаточности и низкой сократительной способностью миокарда была добавлена инотропная терапия (дигоксин 20 мкг/кг). В результате синусовый ритм был восстановлен в течение суток. Продлена инфузия кордарона в дозе 10 мг/кг/сут в течение 5 дней с переходом на 5 мг/кг/сут. Таким образом, в динамике по данным ЭхоКГ: уменьшились размеры камер сердца, внутрисердечных аномалий не было обнаружено. Кровоток в нисходящем отделе аорты пульсирующий, улучшилась сократительная способность миокарда: ФВ возросла — 45–50–62–66 %. Более того, на ЭКГ в динамике наблюдалось восстановление синусового ритма с ЧСС 130 уд/мин, без признаков гипертрофии миокарда и нарушений проводимости. Выводы. В нашем случае лечения эпизода ТП новорожденного —восстановление синусового ритма — достигнуто путем медикаментозной терапии. Альтернативным методом лечения ТП у новорожденных является синхронизированная электрическая кардиоверсия 0,5–1,0 Дж/кг [5, 6].

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Antiarrhythmic Medication in Neonates and Infants with Supraventricular Tachycardia

et al. 2022

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Supraventricular tachycardia (SVT) is the most common arrhythmia in neonates and infants, and pharmacological therapy is recommended to prevent recurrent episodes. This retrospective study aims to describe and analyze the practice patterns, effectiveness, and outcome of drug therapy for SVT in patients within the first year of life. Among the 67 patients analyzed, 48 presented with atrioventricular re-entrant tachycardia, 18 with focal atrial, and one with atrioventricular nodal re-entrant. Fetal tachycardia was reported in 27%. Antiarrhythmic treatment consisted of beta-receptor blocking agents in 42 patients, propafenone in 20, amiodarone in 20, and digoxin in 5. Arrhythmia control was achieved with single drug therapy in 70% of the patients, 21% needed dual therapy, and 6% triple. Propafenone was discontinued in 7 infants due to widening of the QRS complex. After 12 months (6–60), 75% of surviving patients were tachycardia-free and discontinued prophylactic treatment. Patients with fetal tachycardia had a significantly higher risk of persistent tachycardia (p: 0.007). Prophylactic antiarrhythmic medication for SVT in infancy is safe and well tolerated. Arrhythmia control is often achieved with single medication, and after cessation, most patients are free of arrhythmias. Infants with SVT and a history of fetal tachycardia are more prone to suffer from persistent SVT and relapses after cessation of prophylactic antiarrhythmic medication than infants with the first episode of SVT after birth.

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Efficacy and Safety of High-Dose Propranolol for the Management of Infant Supraventricular Tachyarrhythmias

Cited by 31 publications

References 8 publications

Sustained tachyarrhythmia in children younger than 1 year of age: Six year single‐center experience

Sustained tachyarrhythmia in children younger than 1 year of age: Six year single‐center experience

Тахиаритмия У Новорожденных. Клинический Случай Трепетания Предсердий У Новорожденного

Antiarrhythmic Medication in Neonates and Infants with Supraventricular Tachycardia

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