Efficacy and safety of glycosylated undenatured type‐II collagen (UC‐II) in therapy of arthritic dogs^§

Abstract

DeParle L. A., Gupta R. C., Canerdy T. D., Goad J. T., D'Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J. vet. Pharmacol. Therap.28, 385-390. In large breed dogs, arthritis is very common because of obesity, injury, aging, immune disorder, or genetic predispositions. This study was therefore undertaken to evaluate clinical efficacy and safety of undenatured type-II collagen (UC-II) in obese-arthritic dogs. Fifteen dogs in three groups received either no UC-II (Group I) or UC-II with 1 mg/day (Group II) or 10 mg/day (Group III) for 90 days. Lameness and pain were measured on a weekly basis for 120 days (90 days treatment plus 30 days post-treatment). Blood samples were assayed for creatinine and blood urea nitrogen (markers of renal injury); and alanine aminotransferase and aspartate aminotransferase (evidence of hepatic injury). Dogs receiving 1 mg or 10 mg UC-II/day for 90 days showed significant declines in overall pain and pain during limb manipulation and lameness after physical exertion, with 10 mg showed greater improvement. At either dose of UC-II, no adverse effects were noted and no significant changes were noted in serum chemistry, suggesting that UC-II was well tolerated. In addition, dogs receiving UC-II for 90 days showed increased physical activity level. Following UC-II withdrawal for a period of 30 days, all dogs experienced a relapse of overall pain, exercise-associated lameness, and pain upon limb manipulation. These results suggest that daily treatment of arthritic dogs with UC-II ameliorates signs and symptoms of arthritis, and UC-II is well tolerated as no adverse effects were noted.

Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial

“…Native type II collagen has been found to be effective in reducing arthritic pain in animal models [10][11][12] as well as in improving clinical outcomes in patients with rheumatoid arthritis [7][8][9]. However, few studies have evaluated the efficacy of native type II collagen in osteoarthritis [13,14].…”

“…A few studies have evaluated the efficacy of native type II collagen in osteoarthritis. In animal trials, it has been found effective in reducing arthritic pain [10][11][12]. In human trials, native type II collagen has been found effective in increasing functional status and reducing pain [13,14].…”

Anti-Arthritic Efficacy And Safety Of Crominex® 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

“…The placebo group contained only two dogs because IACUC advised us to keep to a minimum number of dogs due to the fact that arthritic dogs suffer from inflammation and pain for a period of five months. Moreover, findings of our previous studies revealed that dogs receiving placebo showed no improvement in arthritis pain [19][20][21][22][23]. Nine dogs in Group-II received Crominex 3+ (500µg of trivalent chromium, 7.5 mg Phyllanthus emblica extract, and 7.5 mg purified Shilajit) twice daily (one capsule before morning meal and one capsule before evening meal) for a period of five months.…”

“…Pain after limb manipulation, on a scale of 0-4, was evaluated as: 0, no pain; 1, mild pain; 2, moderate pain; 3, severe pain; and 4, severe and constant pain. Pain after physical exertion, on a disease modifying agents and physical therapy with acupuncture have been used [19][20][21][22][23][31][32][33][34][35]. In the recent past, to manage OA in canine patients, most veterinarians have commonly used cyclooxygenase (COX) inhibiting non-steroidal anti-inflammatory drugs (NSAIDS), such as deracoxib, etodolac, carprofen, firocoxib, ketoprofen, meloxicam, rofecoxib, tepoxalin and others [36,37].…”

“…These cascading events lead to increased friction and inflammation in the joints. To date, there are no serum, urinary or synovial biomarkers that are specific and validated for OA [18].Common signs and symptoms associated with OA in dogs include limping, immobility, stiffness of joints, crepitus, periarticular swelling, palpable effusion, pain upon manipulation of the joint and lameness [10,[19][20][21][22][23][24][25]. The diagnosis of OA in canine patients is based upon history, physical exam and radiographic evidence.…”