2018
DOI: 10.1182/blood-2018-99-113718
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Efficacy and Safety of Generic Imatinib Compared to Glivec in Chronic Phase - Chronic Myeloid Leukemia - a Multicenter, Observational Study

Abstract: Glivec was the first tyrosine kinase inhibitor (TKI) approved for chronic myeloid leukemia (CML) treatment and its efficacy has been demonstrated in a large number of trials. Generic formulations have been used recently as a more cost effective treatment, but there are few studies that have prospectively evaluated the efficacy and safety of these drugs.Aims: The present study aimed to evaluate the efficacy and safety of generic imatinib in CP-CML in first line therapy. Methods: This is a multicenter, observati… Show more

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“…On the other hand, Pagnano et al published their observational multi-center (Argentina, Brasil and Italy) study on 445 (original n = 285, generic n = 160) CML patients and found that generic imatinib was inferior to original molecule in terms of treatment failure at 3 months, EFS, PFS and OS at 24 months [14].…”
Section: Declarations Con Ict Of Interestmentioning
confidence: 99%
“…On the other hand, Pagnano et al published their observational multi-center (Argentina, Brasil and Italy) study on 445 (original n = 285, generic n = 160) CML patients and found that generic imatinib was inferior to original molecule in terms of treatment failure at 3 months, EFS, PFS and OS at 24 months [14].…”
Section: Declarations Con Ict Of Interestmentioning
confidence: 99%