2019
DOI: 10.1155/2019/9728957
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Efficacy and Safety of Fuzi Formulae on the Treatment of Heart Failure as Complementary Therapy: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Abstract: Objective. Heart failure is a major public health problem worldwide nowadays. However, the morbidity, mortality, and awareness of heart failure are not satisfied as well as the status of current treatments. According to the standard treatment for chronic heart failure (CHFST), Fuzi (the seminal root of Aconitum carmichaelii Debx.) formulae are widely used as a complementary treatment for heart failure in clinical practice for a long time. We are aiming to assess the efficacy and safety of Fuzi formulae (FZF) o… Show more

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Cited by 11 publications
(8 citation statements)
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“…Complementary and alternative medicine therapies have become increasingly popular and are used regularly by patients with chronic disorders [9]. Currently, the combination of traditional Chinese medicine (TCM) and western medicine has been widely used for the CHF treatment [10][11][12]. According to the perspective of TCM, the etiology of CHF is the yang deficiency of heart which is the result of the inadequacy of Qi and blood, blood stasis, and phlegm-dampness.…”
Section: Introductionmentioning
confidence: 99%
“…Complementary and alternative medicine therapies have become increasingly popular and are used regularly by patients with chronic disorders [9]. Currently, the combination of traditional Chinese medicine (TCM) and western medicine has been widely used for the CHF treatment [10][11][12]. According to the perspective of TCM, the etiology of CHF is the yang deficiency of heart which is the result of the inadequacy of Qi and blood, blood stasis, and phlegm-dampness.…”
Section: Introductionmentioning
confidence: 99%
“…Research on PGJXD has generally focused more on assessing its cardiac function and studying classic drug pairs in the formula, but the investigation of the material basis of the entire PGJXD formula and the development of dosage rules have not been reported in the literature 16,17 . With the goal of establishing an efficient quality control and compositional analysis system for PGJXD, and to explore comprehensively the scientific connotations of the rules of compounding, this article comprehensively reveals the impact of each ingredient compatibility on its overall chemical composition from the “point” of single drugs, drug pairs and split formula group research to the “surface” of compound formula research, in order to reveal the theoretical underpinnings and potential mechanism of action of PGJXD compatibility.…”
Section: Discussionmentioning
confidence: 99%
“…PGJXD is made up of processed A. carmichaelii (PAC, 150 g), Zingiber officinale (Zor, 60 g), Glycyrrhiza uralensis (Gly, 60 g), Cornus officinalis (Cor, 120 g), keel (30 g), oyster powder (30 g), live magnet (30 g), ginseng (30 g, separately decocted in thick juice) and musk (0.5 g, divided into two doses) 16 . The current research on this formula is primarily focused on the assessment of cardiac function and the composition of the monarch A. carmichaelii 17 . However, greatly lacking is the analysis of the chemical compositions and rules of this formula.…”
Section: Introductionmentioning
confidence: 99%
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“…It has been reported that Shensong Yangxin capsules, a combined herbal formulation widely used in China for the treatment of arrhythmias, have the benefits of suppressing ventricular premature complexes (VPCs) and improving cardiac function ( Wang X. et al, 2017 ). Yang et al (2019 ) assessed the efficacy and safety of Fuzi formulae (FZF) in treating CHF, and they demonstrated that FZF exerts efficacy and additional benefits on CHF. It has also been reported that gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure ( Jin et al, 2018 ), and it can produce benefits for vascular calcification ( Kee et al, 2014 ), cardiac hypertrophy, and fibrosis ( Ryu et al, 2016 ), hypertension ( Jin et al, 2017a ), and oxidative stress ( Jin et al, 2017b ).…”
Section: Introductionmentioning
confidence: 99%