Efficacy and safety of fruquintinib as third- or further-line therapy for patients with advanced bone and soft tissue sarcoma: a multicenter retrospective study

Abstract

Purpose Fruquintinib is an oral small-molecule angiogenesis inhibitor, markedly specifically inhibited vascular endothelial growth factor 2 (VEGFR2). This retrospective study aimed to evaluate the safety and efficacy of fruquintinib, or in combination with immunotherapy or chemotherapy in patients with bone and soft tissue sarcoma (STS), who have failed at least secondary-line treatment. Patients and methods We performed a retrospective analysis of advanced bone and STS patients who received fruquintinib containing third- or further-line therapy in Shanghai Jiao Tong University Affiliated Sixth People’s and the Affiliated Hospital of Jiangxi University of Traditional Chiese Medicine from September 2019 to February 2022. All of them had accepted at least anthracyclines-based chemotherapy. For the experimental group, 25 cases, the patients took a basic dose of fruquintinib 3–5 mg once a day for 21 days per 4 weeks as a cycle until the disease progression or intolerable toxicity. The other 20 patients in the control group received the best supportive care. The patients were evaluated by computed tomography (CT) or MRI once 2 months or symptoms worse. The DCR, progression-free survival (PFS), and adverse reactions of the drug were recorded and reviewed. Results The DCR in patients receiving fruquintinib therapy was 80.0%. The median PFS (mPFS) in the fruquintinib-containing therapy group was significantly longer than that in the control group (4.8 vs. 1.4 months; P < 0.001). The mPFS in the fruquintinib group, the fruquintinib-OI group and the fruquintinib-chemotherapy group were 3.2 months [95% confidence interval (CI), 2.0–7.9], 4.9 months (95% CI, 3.0–9.9) and 4.2 months (95% CI, 2.6–6.6) respectively, all of them were longer than the mPFS of 1.4 months (95% CI, 0.3–2.5) in the control group (P < 0.001). Conclusion Fruquintinib was reported for the first time to have favorable efficacy and safety as an optional treatment for patients with advanced bone and STS who failed in multi-line therapies.

Safety and efficacy of fruquintinib‐based therapy in patients with advanced or metastatic sarcoma

“…In a report by Ding X and his colleagues, fruquintinib was demonstrated as a petential third‐ or further‐line treatment for patients with advanced sarcoma. The mPFS for the fruquintinib‐based group and the control group were 4.8 versus 1.4 months ( p < 0.001), respectively 28 . Anlotinib showed a mPFS of 4.8 months in patients with advanced osteosarcoma who had previously received intensive treatment 14 .…”

“…The mPFS for the fruquintinib-based group and the control group were 4.8 versus 1.4 months (p < 0.001), respectively. 28 Anlotinib showed a mPFS of 4.8 months in patients with advanced osteosarcoma who had previously received intensive treatment. 14 Cabozantinib was used to treat advanced osteosarcoma with no limit on the number of previous lines of treatment.…”