Efficacy and safety of fosphenytoin for benign convulsions with mild gastroenteritis

Nakazawa, Mika; Toda, Soichiro; Abe, Shinpei; Ikeno, Mitsuru; Igarashi, Ayuko; Nakahara, Eri; Yamashita, Shintaro; Niijima, Shinichi; Shimizu, Toshiaki; Okumura, Akihisa

doi:10.1016/j.braindev.2015.02.001

Cited by 14 publications

(16 citation statements)

References 11 publications

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“…PHT and fos-PHT are reported to be useful for BISMG in 66.7-80.0% of patients and 87.5%, respectively [4,8,20]. In the present study, PHT/fos-PHT was effective in 75.0% of patients, which is consistent with previous reports.…”

Section: Discussionsupporting

confidence: 92%

Effects of various antiepileptic drugs in benign infantile seizures with mild gastroenteritis

Kikuchi

Hamano

Matsuura

et al. 2017

E&S

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Purpose: This study sought to deter mine the appr opr iate choice of antiepileptic dr ugs (AEDs) for seizures during the acute phase in patients with benign infantile seizures with mild gastroenteritis (BISMG). Methods: We retrospectively investigated the efficacy and dose of AEDs for BISMG by reviewing the medical records of 42 patients diagnosed with BISMG. In this study, AEDs were regarded as effective when seizures ceased for >24 h after administration. Results: AEDs were administered to 39 of 42 patients (92.9%). Carbamazepine was effective in 21 of 21 patients (100.0%), phenytoin/fos-phenytoin in three of four patients (75.0%), midazolam in one of two patients (50.0%), lidocaine in one of two patients (50.0%), and diazepam in 13 of 36 patients (36.1%). Intravenous diazepam was effective in seven of 11 patients (63.6%) and suppository diazepam in 10 of 25 patients (40.0%). The median dose of carbamazepine was 5.0 mg/kg/day (range, 3.0-5.0 mg/kg/day) and the median duration of medication was 1 day (range, 1-5 days). Conclusion: Tr eatment for 1 day with low-dose carbamazepine was effective for BISMG. Phenytoin/fosphenytoin and intravenous diazepam, not but suppository diazepam, were also effective. We recommend 1 day of treatment with low-dose carbamazepine as the first-line treatment for BISMG. The unnecessary use of AEDs for BISMG should be avoided after the acute phase because seizures in BISMG rarely recur.

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Section: Discussionsupporting

confidence: 92%

Effects of various antiepileptic drugs in benign infantile seizures with mild gastroenteritis

Kikuchi

Hamano

Matsuura

et al. 2017

E&S

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“…The rate of seizure cessation following treatment with fPHT was 65% in a study of pediatric patients with status epilepticus [8]. The rate of prevention of seizure recurrence following treatment with fPHT was reported to be 81% in adults after status epilepticus [11] and 87% in children with benign convulsions with mild gastroenteritis [9]. The rate of seizure cessation following treatment with cMDL as second-line therapy was reported to be 49% in pediatric patients with status epilepticus [7].…”

Section: Discussionmentioning

confidence: 99%

“…There are several reports regarding efficacy of fPHT or cMDL treatment [7][8][9]11]. fPHT has been reported to be effective in a few retrospective studies [8,9,11]. The rate of seizure cessation following treatment with fPHT was 65% in a study of pediatric patients with status epilepticus [8].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, continuous intravenous midazolam (cMDL) had commonly been used as second-line treatment for pediatric status epilepticus in Japan [6,7]. The efficacies of fPHT and cMDL have been reported in several previous studies [7][8][9]. However, reports on the adverse effects of these therapies, specifically central nervous system (CNS) depression, are limited [7].…”

Section: Introductionmentioning

confidence: 99%

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Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus

Nishiyama

Nagase

Tomioka

et al. 2018

Brain and Development

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“…However, use of anticonvulsants during the acute stage is required for children with prolonged or repeated seizures. [8][9][10][11] The aim of this study is to investigate the factors affecting the number and duration of seizures in CwG which may influence on decision of administration of anticonvulsants.…”

Section: Introductionmentioning

confidence: 99%

Older Patients May Have More Frequent Seizures among Children Diagnosed as Benign Convulsions with Mild Gastroenteritis

You

2020

Neuropediatrics

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Purpose Benign convulsions with mild gastroenteritis (CwG) is a condition that does not usually require treatment. However, when the patient experiences multiple seizures or prolonged seizures, anticonvulsant treatment may be required. We investigated this study to identify the factors that may influence on the number or duration of seizures at CwG. Methods We retrospectively analyzed the medical records of CwG patients who were admitted to the Department of Pediatrics at Sanggye Paik Hospital. Results A total of 105 children with CwG were enrolled. The mean age was 19.59 ± 7.09 months. The mean duration of seizure was 2.79 ± 5.51 minutes and mean number of seizure was 2.33 ± 1.70. Sixty-nine children had seizures less than twice, whereas 36 experienced three times or more. These groups differed significantly according to age in CwG (18.16 ± 7.08, vs. 22.33 ± 6.34 months, p < 0.05). When patients were divided into two groups based on age in CwG using a cut-off of 20 months, we found significant differences in seizure number (1.91 ± 1.27 vs. 3.11 ± 2.10, p < 0.05). There was also a positive correlation between patient age and frequency of seizures (R = 0.316, p = 0.001). Patients who received anticonvulsants were older (17.60 ± 6.87 vs. 22.04 ± 6.63 months, p < 0.05) and had more frequent (1.59 ± 1.37 vs. 3.26 ± 1.63, p < 0.05) and longer seizures (1.76 ± 2.75 vs. 4.07 ± 7.49 minutes, p < 0.05). Conclusion As the number of seizure in CwG was associated with age, treatment in older children may be required in acute stage.

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Efficacy and safety of fosphenytoin for benign convulsions with mild gastroenteritis

Cited by 14 publications

References 11 publications

Effects of various antiepileptic drugs in benign infantile seizures with mild gastroenteritis

Effects of various antiepileptic drugs in benign infantile seizures with mild gastroenteritis

Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus

Older Patients May Have More Frequent Seizures among Children Diagnosed as Benign Convulsions with Mild Gastroenteritis

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