Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in pre–school-age children with asthma: A randomized, double-blind, placebo-controlled study

Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis

“…Seven studies comparing daily ICS with placebo (N = 1336) reported on symptom-free days (SFDs); 7,22,24,[30][31][32]37 however, few provided adequate data for metaanalysis. Six of these studies 31 found a benefit with daily ICS, with mean differences in percentage of SFDs ranging from 5% to 23%.…”

“…Six of these studies 31 found a benefit with daily ICS, with mean differences in percentage of SFDs ranging from 5% to 23%. Two studies that compared daily and intermittent ICS 30,39 (N = 498) found no difference in SFDs.…”

Achieving control of asthma in preschoolers

“…53 Fluticasone 100 μg twice daily for 12 weeks caused little change in urinary excretion of cortisol and no significant change in rate of linear growth. 54 Conversely, in a large recent study of children 2-3 years of age at risk for asthma, fluticasone 100 μg twice daily for 2 years significantly reduced the mean increase in height by 1.1 cm at 24 months, with some catch-up growth apparently occurring after cessation of the inhaled corticosteroids. 38 However, in school-aged children, ciclesonide 200 μg daily for 1 year had no effect on linear growth velocity.…”

Identifying and managing the infant and toddler at risk for asthma

“…Their treatment recommendations were based on review of the key studies in preschool-aged children with a history of recurrent wheezing or asthma, as summarized in Table II. [7][8][9][10][11][12][13][14][15][16][17][18][19] The NAEPP acknowledged that inhaled corticosteroid (ICS) therapy in preschool children with recurrent wheeze does not alter the natural course of the disease; however, they have recommended the use of daily controller therapy for recurrent wheezing to decrease the risk and impairment of the disease in this age group. This recommendation was based in part on the results of a previous study.…”