Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain: a Systematic review and meta-analysis

Weng, Chenghua; Xu, Jiajun; Wang, Q.; Lu, Wentian; Liu, Z.

doi:10.1016/j.joca.2020.03.001

Cited by 36 publications

(37 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The analgesic effect of duloxetine in patients with centrally mediated pain due to OA is well documented. [10,25] From the results of this study, approaches to the pathology of CS may be important for hip OA patients with pain, particularly, pain at rest.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Central Sensitization Inventory scores correlate with pain at rest in patients with hip osteoarthritis: A retrospective study

Ohashi

Fukushima

Inoue

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Patients with persistent pain due to osteoarthritis (OA) complain of multiple symptoms that cannot be explained solely by structural changes. A poor correlation exists between structural and inflammatory changes in OA and pain levels. Central sensitization (CS) has been identified as a factor that induces chronic pain in patients with OA. Although it is important to identify osteoarthritis patients with CS components, the prevalence and characteristics of CS, especially those in patients with hip OA, are not well understood. Thus, we aimed to determine the prevalence and characteristics of CS in patients with hip OA, in this study. Methods: The CS Inventory (CSI), used as a non-invasive routine clinical tool to evaluate the presence of CS 1 month before surgery in 100 patients with hip OA, was measured at our outpatient clinic, and the data were retrospectively reviewed. We determined the number of patients with a CSI score of 40 points or higher and assessed the relationships between the CSI score and clinical factors (including age, duration of hip pain, degree pain at rest and on activity, by using the visual analogue scale [VAS] and the Harris Hip Score) using the Spearman’s correlation coefficient. Results: The mean age of participants was 63.9±11.6 years, and there were 15 men and 85 women. All patients had hip OA, categorised as advanced and terminal stage (Tönnis grade 2–3) on preoperative plain radiography. The mean duration of hip pain was 4.2±4.4 years. The mean CSI score was 19.5±11.3 and 5 (5.0%) of the patients had a score of 40 or more points. CSI scores correlated significantly only with VAS pain at rest (r=0.348, P<0.001). Conclusion: In this study, 1 out of every 20 hip OA patients had CS components. CSI scores were significantly correlated with pain at rest in hip OA patients. CS approaches to hip OA may be one of the treatment options for pain at rest.

show abstract

Section: Discussionmentioning

confidence: 90%

“…[8] In recent years, some treatments have been reported for OA patients with CS components. [8][9][10][11] While it is important to identify OA patients with CS components, the prevalence and characteristics of CS, especially in patients with hip OA, are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Central Sensitization Inventory scores correlate with pain at rest in patients with hip osteoarthritis: A retrospective study

Ohashi

Fukushima

Inoue

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, some treatments of OA pain related to CS components have been reported [8][9][10][11]. Duloxetine is a potent selective serotonin norepinephrine reuptake inhibitor that potentiates the descending inhibitory pain pathways in the central nervous system [24].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with chronic pain with CS components have been reported to be resistant to conservative treatment, including traditional physiotherapy and pain medication [8]. In recent years, some treatments have been reported for OA patients with CS components [8][9][10][11]. While it is important to identify OA patients with CS components, the prevalence and characteristics of CS, especially in patients with hip OA, are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Central sensitization inventory scores correlate with pain at rest in patients with hip osteoarthritis: a retrospective study

Ohashi

Fukushima

Inoue

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background: Patients with persistent pain due to osteoarthritis (OA) complain of multiple symptoms that cannot be explained solely by structural changes. A poor correlation exists between structural and inflammatory changes in OA and pain levels. Central sensitization (CS) has been identified as a factor that induces chronic pain in patients with OA. Although it is important to identify osteoarthritis patients with CS components, the prevalence and characteristics of CS, especially those in patients with hip OA, are not well understood. Thus, we aimed to determine the prevalence and characteristics of CS in patients with hip OA, in this study. Methods: The CS Inventory (CSI), used as a non-invasive routine clinical tool to evaluate the presence of CS 1 month before surgery in 100 patients with hip OA, was measured at our outpatient clinic, and the data were retrospectively reviewed. We determined the number of patients with a CSI score of 40 points or higher and assessed the relationships between the CSI score and clinical factors (including age, duration of hip pain, degree pain at rest and on activity, by using the visual analogue scale [VAS] and the Harris Hip Score) using the Spearman's correlation coefficient. Results: The mean age of participants was 63.9 ± 11.6 years, and there were 15 men and 85 women. All patients had hip OA, categorised as advanced and terminal stage (Tönnis grade 2-3) on preoperative plain radiography. The mean duration of hip pain was 4.2 ± 4.4 years. The mean CSI score was 19.5 ± 11.3 and 5 (5.0%) of the patients had a score of 40 or more points. CSI scores correlated significantly only with VAS pain at rest (r = 0.348, P < 0.001). Conclusion: In this study, 1 out of every 20 hip OA patients had CS components. CSI scores were significantly correlated with pain at rest in hip OApatients. CS approaches to hip OA may be one of the treatment options for pain at rest.

show abstract

“…14 As a standard treatment for administration of the analgesics, the recommended agents for neuropathic pain have been Pregabalin (evidence level 1A), duloxetine hydrochloride (Cymbalta) (1A), and Amitriptyline Hydrochloride (Tryptanol) (1B). 15 Duloxetine is categorized as serotonin and noradrenaline reuptake inhibitor (SNRI), that is effective for depressive state. It has been widely used for diabetic neuropathy.…”

mentioning

confidence: 99%

Recent Tendency of Therapeutic Medical Agents for Diabetic Peripheral Neuropathic Pain

Bando¹

2020

Diabetes Res Open J

View full text Add to dashboard Cite

Recently, elder patients tend to have neuropathic pain such as lower back and joints pain, stiff shoulders, besides diabetic neuropathy. Typical peripheral neuropathic pain includes diabetic peripheral neuropathic pain (DPNP), postherpetic neuralgia (PHN) and chronic pain due to herniated disc. Three analgesic agents are described. Pregabalin (Lyrica ®) has been prevalent worldwide. However, it has been provided for several diseases for off-label administration, which has been one of the clinical problems.Mirogabalin (Tarlige ®) has revealed efficacy for DPNP in a dose-dependent manner. Duloxetine hydrochloride (Cymbalta ®) has efficacy for pain and also depression as serotonin and noradrenaline reuptake inhibitor (SNRI).

show abstract

Efficacy and safety of duloxetine in osteoarthritis or chronic low back pain: a Systematic review and meta-analysis

Cited by 36 publications

References 48 publications

Central Sensitization Inventory scores correlate with pain at rest in patients with hip osteoarthritis: A retrospective study

Central Sensitization Inventory scores correlate with pain at rest in patients with hip osteoarthritis: A retrospective study

Central sensitization inventory scores correlate with pain at rest in patients with hip osteoarthritis: a retrospective study

Recent Tendency of Therapeutic Medical Agents for Diabetic Peripheral Neuropathic Pain

Contact Info

Product

Resources

About