“…With 60 mg/day of DLX in elderly MDD patients, the most frequently reported ADRs were dry mouth and moderate nausea, and at rates similar to those reported with several SRIs in older patients, and without appreciable increases or decreases in blood pressure or pulse than with a PBO or SRIs (Raskin et al, 2008a). However, other studies have reported higher rates of treatment-related nausea with DLX than PBO or SRIs (Detke et al, 2002a,b;Goldstein et al, 2004;Brannan et al, 2005;Perahia et al, 2006bPerahia et al, , 2008Brecht et al, 2007;Lee et al, 2007;Nierenberg et al, 2007;Dunner et al, 2008). In one open label trial with more prolonged treatment with DLX, newly arising ADRs were rare, but some symptoms have been reported (Dunner et al, 2008) to begin or increase (e.g., decreased libido, abnormal orgasms, weight-gain orloss, hypersomnia, night-sweats, nightmares or early awakening, increased blood pressure, tachycardia, tremor, dizziness or unsteadiness, aggression, hypomania, or suicidal ideation).…”