Efficacy and safety of conventional versus daylight photodynamic therapy in children affected by multiple facial flat warts

Borgia, Francesco; Giuffrida, Roberta; Coppola, Marialorena; Princiotta, Rosaria; Vaccaro, Mario; Guarneri, Fabrizio; Cannavò, Serafinella Patrizia

doi:10.1016/j.pdpdt.2020.101819

Cited by 16 publications

(15 citation statements)

References 21 publications

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“…Apart from cryotherapy, other mechanical therapies that have been studied for the treatment of cutaneous warts in children include curettage, electrocautery, carbon dioxide (CO 2 ) laser, pulsed dye laser, and superficial radiotherapy. The clearance rates were 59.7% for curettage, 50% for electrocautery, 57.1% for CO2 laser, 33.6% for pulsed dye laser, 100.0% for long‐pulsed 1064 nm Nd:YAG laser, 95.7% for superficial radiotherapy, 73.3% for conventional photodynamic therapy and 80.0% for daylight photodynamic therapy 14,17,36,49‐53 . Pain is the most common side‐effect of these treatment modalities and may not suitable for use in younger patients.…”

Section: Resultsmentioning

confidence: 99%

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Treatment of cutaneous viral warts in children: A review

Soenjoyo

Chua

Wee

et al. 2020

Dermatologic Therapy

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Viral warts or verruca are very common skin infections in children. Although benign, lesions can be extensive, painful, bleed, or lead to cosmetic disfigurement. Although spontaneous resolution can occur, parents often bring their children for treatment, especially when they are symptomatic. Many publications have assessed the efficacy and safety of treatment of warts in adults. However, treatment in children can be challenging due to their immune responses and lower threshold for pain. We review the current literature on the methods, efficacy, and side effect profile of common treatment modalities for cutaneous viral warts in children. There is evidence that salicylic acid and cryotherapy are effective, and although cryotherapy is more effective, there is a higher risk of side effects such as pain and blistering. Combination treatment with salicylic acid and cryotherapy may reduce these side effects. Although there is limited data, other treatment options such as cantharidin, immunotherapy and other mechanical therapies, for example, carbon dioxide lasers, may also be considered, especially for recalcitrant lesions.

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Section: Resultsmentioning

confidence: 99%

“…Some, like MMR and candida require intralesional administration which may be too painful for use in pediatric patients. 14,17,36,[49][50][51][52][53] Pain is the most common side-effect of these treatment modalities and may not suitable for use in younger patients.…”

Section: Salicylic Acid (Sa) Monotherapy and Combination Therapiesmentioning

confidence: 99%

Treatment of cutaneous viral warts in children: A review

Soenjoyo

Chua

Wee

et al. 2020

Dermatologic Therapy

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“…Generally, cryotherapy is not recommended for younger patients, as it has been commonly associated with pain and discomfort [ 113 , 114 ]. Warts can also be treated with salicylic acid [ 117 ], a natural plant extract with anti-inflammatory and antibacterial properties [ 113 ]. Despite its good efficacy, salicylic acid treatment requires daily application over the course of a few weeks and/or months.…”

Section: Skin Infectionsmentioning

confidence: 99%

“…Some other, less effective topical methods include treatment with formaldehyde, glutaraldehyde, and silver nitrate among others [ 111 , 114 , 116 ]. All mentioned therapies are widely used, but neither is suitable for treating resistant plantar warts [ 113 , 117 ]. Warts, alongside other skin infections, can have a severe impact on health and viral transmission [ 113 , 114 ].…”

Section: Skin Infectionsmentioning

confidence: 99%

“…The clearance rate was affected by the size, position, age, and number of warts [ 121 ]. A study by Borgia et al compared conventional to daylight ALA-PDT in treating facial flat warts in children [ 117 ]. Conventional ALA-PDT (10% ALA, 630 nm) had more rapid response, but the general therapeutic performance was superior in daylight ALA-PDT (10% ALA, 2 h daylight exposure).…”

Section: Skin Infectionsmentioning

confidence: 99%

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Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light

et al. 2022

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which caused the COVID-19 pandemic spreading around the world from late 2019, served as a ruthless reminder of the threat viruses pose to global public health. The synthesis of new antiviral drugs, as well as repurposing existing products, is a long-term ongoing process which has challenged the scientific community. One solution could be an effective, accessible, and rapidly available antiviral treatment based on phototherapy (PT). PT has been used to treat several diseases, and relies on the absorption of light by endogenous molecules or exogenous photosensitizers (PS). PT has often been used in cancer treatment and prophylaxis, and as a complement to established chemotherapy and immunotherapy in combined therapeutic strategy. Besides significant applications in anticancer treatment, studies have demonstrated the beneficial impact of PT on respiratory, systemic, emerging, and oncogenic viral infections. The aim of this review was to highlight the potential of PT to combat viral infections by summarizing current progress in photodynamic, photothermal, and photoacoustic approaches. Attention is drawn to the virucidal effect of PT on systemic viruses such as the human immunodeficiency virus and human herpes viruses, including the causative agent of Kaposi sarcoma, human herpes virus (HHV8). PT has good potential for disinfection in anti-norovirus research and against pandemic viruses like SARS-CoV-2.

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Principles of Photodynamic Therapy

Ibbotson,

McKenna

2024

Rook's Textbook of Dermatology

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Topical photodynamic therapy (PDT) is widely used as an effective and well‐tolerated treatment for field change actinic keratosis, Bowen disease and superficial basal cell carcinoma. There is a strong evidence base to support its use and guidelines, which summarise the evidence and clinical utility of this therapy. There are also standards available for guidance with respect to establishing PDT services in dermatology and emphasis is placed on the availability of PDT for practitioners affiliated with a skin cancer multi‐disciplinary team. Developments in photosensitisers and light delivery, such as through the increasing application of daylight PDT, have greatly improved the tolerance, acceptability and uptake of PDT, such that this should be widely available through dermatology services. Further refinements in photosensitiser and light delivery will be expected to continue to improve PDT outcomes and the uptake of this invaluable therapeutic approach.

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Efficacy and safety of conventional versus daylight photodynamic therapy in children affected by multiple facial flat warts

Cited by 16 publications

References 21 publications

Treatment of cutaneous viral warts in children: A review

Treatment of cutaneous viral warts in children: A review

Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light

Principles of Photodynamic Therapy

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