Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats

Ibrahim, Mohamed; Abdelzaher, Walaa Yehia; Rofaeil, Remon Roshdy; Abdelwahab, Sayed F.

doi:10.1016/j.biopha.2018.01.102

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…The findings reported by Pei et al, (2018) are in contrast with the results of the current work regarding the analgesic effect of tizanidine in neuropathic pain and this controversy may be attributed to the difference in the route of administration of tizanidine where in the present study tizanidine was given ip in a single dose but in Pei et al, (2018) study tizanidine was given intrathecal for 3 consecutive days after injury. Concerning the drug combination of gabapentin and diclofenac the present results cope with Ibrahim et al, (30) who revealed that combination therapy of low dose of either diclofenac with gabapentin showed higher analgesic effect compared with their individual high doses. Regarding combination of gabapentin and tizanidine, the present results cope with Cheng (31) who stated that the addition of α2-agonists might enhance GABAergic and glycinergic antinociception and have been applied to chronic pain.…”

Section: Table (3): Percentage Changes In the Mrt Compared To The Post-carragenan Control After Ip Injection Of {Gabapentin (100 Mg/kg) +supporting

confidence: 84%

Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats

Zayed

Kamel

abdelsamee

et al. 2019

Zagazig University Medical Journal

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Background: Pain is an unpleasant sensation experienced when tissues are damaged. Therapeutic management of pain requires consideration of many factors due multiplicity of etiopathogenesis. Objectives: The present study was designed to assess and compare the analgesic effects of gabapentin, diclofenac and tizanidine as well as their combinations in acute and chronic pain. Methods: 128 rats were randomly allocated into two main equal categories; one for acute inflammatory and other for chronic neuropathic pain study. The acute category was divided into 8 equal groups; control, carrageenan, diclofenac, gabapentin, tizanidine, gabapentin-diclofenac, gabapentintizanidine and tizanidine-diclofenac groups. Acute inflammatory pain was induced by carrageenan injection in the animals paw. In the chronic category neuropathic pain was induced by right sciatic nerve ligation except for control and sham groups. This category was divided into; control, sham, gabapentin, tizanidine, gabapentin-diclofenac, gabapentin-tizanidine and tizanidinediclofenac groups. The mean reaction time was assessed in all groups. Results: In acute pain the three drugs and their combinations had significant analgesic effects. Tizanidine potentiated the analgesic effects of diclofenac and gabapentin. In chronic neuropathic pain diclofenac and gabapentin had significant analgesic action while, tizanidine had no analgesic effect. Conclusion: Tizanidine didn't show analgesic effect on chronic pain but potentiated the analgesic effect of gabapentin and diclofenac in acute pain model.

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Section: Table (3): Percentage Changes In the Mrt Compared To The Post-carragenan Control After Ip Injection Of {Gabapentin (100 Mg/kg) +supporting

confidence: 84%

Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats

Zayed

Kamel

abdelsamee

et al. 2019

Zagazig University Medical Journal

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“…The recovery of sensory function of the injured nerve was assessed by a hind paw thermal withdrawal test using a hot-plate instrument (Muromachi Kikai, Tokyo, Japan) as previously described (Gallaher and Steward, 2018; Ibrahim et al, 2018). Before performing the test, each mouse was habituated twice to the hot plate set to room temperature.…”

Section: Methodsmentioning

confidence: 99%

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

Fan

et al. 2019

Front. Cell. Neurosci.

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Ascorbic acid (AA) is an essential micronutrient that has been safely used in the clinic for many years. The present study indicates that AA has an unexpected function in facilitating nerve regeneration. Using a mouse model of sciatic nerve crush injury, we found that AA can significantly accelerate axonal regrowth in the early stage [3 days post-injury (dpi)], a finding that was revealed by immunostaining and Western blotting for antibodies against GAP-43 and SCG10. On day 28 post-injury, histomorphometric assessments demonstrated that AA treatment increased the density, size, and remyelination of regenerated axons in the injured nerve and alleviated myoatrophy in the gastrocnemius. Moreover, the results from various behavioral tests and electrophysiological assays revealed that nerve injury-derived functional defects in motor and sensory behavior as well as in nerve conduction were significantly attenuated by treatment with AA. The potential mechanisms of AA in nerve regeneration were further explored by investigating the effects of AA on three types of cells involved in this process [neurons, Schwann cells (SCs) and macrophages] through a series of experiments. Overall, the data illustrated that AA treatment in cultured dorsal root ganglionic neurons resulted in increased neurite growth and lower expression of RhoA, which is an important inhibitory factor in neural regeneration. In SCs, proliferation, phagocytosis, and neurotrophin expression were all enhanced by AA. Meanwhile, AA treatment also improved proliferation, migration, phagocytosis, and anti-inflammatory polarization in macrophages. In conclusion, this study demonstrated that treatment with AA can promote the morphological and functional recovery of injured peripheral nerves and that this effect is potentially due to AA’s bioeffects on neurons, SCs and macrophages, three of most important types of cells involved in nerve injury and regeneration.

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“…It is expressed and significantly increased by tumor cells and stromal cells in an inflammatory state (16). The action of COX-2 can convert arachidonic acid into prostaglandins, leading to the synthesis and accumulation of inflammatory substances, causing edema, local inflammation, and pain (17). More studies have shown that the release of inflammatory factors [such as tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), IL-6, and so on] from tumors and surrounding inflammatory cells is closely related to the occurrence of neuropathic pain, and the increase of inflammatory factors is associated with the severity of pain.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy evaluation and prevention of adverse reactions in a randomized trial of a combination of three drugs in the treatment of cancerous pudendal neuralgia

et al. 2021

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Background: To explore the clinical efficacy, safety, and prevention of major adverse reactions of the nonsteroidal anti-inflammatory drug celecoxib combined with OxyContin and Pregabalin in the treatment of cancerous pudendal neuralgia.Methods: A total of 51 patients presenting with pelvic malignancies with cancerous pudendal neuralgia were selected, and random number table method was used to allocate them to either the experimental group (n=27) or control group (n=24). The control group was treated with OxyContin combined with Pregabalin, and the experimental group was treated with Celecoxib on the basis of the control group.Results: At 24 hours after treatment, the clinical effective rate of the experimental group was 92.6%, which was significantly higher than the 66.7% of the control group (P<0.05). The numerical rating scale (NRS) scores of the 2 groups of participants on the 7th and 14th days after treatment were lower than before treatment (P<0.05), and the NRS scores of the participants in the experimental group had decreased more significantly. At the same time, the average daily consumption of OxyContin on the 7th and 14th day of the experimental group was lower than that of the control group (P<0.05). Compared with the control group, the incidence of constipation and dysuria in the experimental group was significantly reduced (P<0.05).Co-occurring in both groups during treatment, 10 participants with urinary dysfunction were treated with tamsulosin hydrochloride sustained-release capsules, no urinary retention occurred, catheterization was avoided, tamsulosin hydrochloride sustained-release capsules could be stopped after 1 week, and urination was smooth (P<0.05). After treatment, the quality of life of the 2 groups of participants had improved compared to before treatment, and the improvement was more significant in the experimental group.Conclusions: When treating patients with cancerous pudendal neuralgia with OxyContin and Pregabalin, the addition of celecoxib has a significant effect, which can effectively improve the patient's pain, improve their quality of life to a certain extent, and reduce the consumption of OxyContin. Lowering the dose of OxyContin reduces the occurrence of adverse reactions related to the drug, especially the incidence of constipation and urinary retention. Tamsulosin hydrochloride sustained-release capsules can effectively relieve urinary disorders caused by OxyContin.

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Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats

Cited by 13 publications

References 34 publications

Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats

Comparison between the analgesic effect of Tizanidine, Diclofenac and Gabapbentin on experimentally induced acute and chronic pain in male albino rats

Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

Clinical efficacy evaluation and prevention of adverse reactions in a randomized trial of a combination of three drugs in the treatment of cancerous pudendal neuralgia

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