“…In four trials, DH was associated with a higher risk of any gastrointestinal symptoms compared with SH (RD 0.18, 95% CI 0.08 to 0.27, P < 0.001, I 2 = 0%), compared with SAP/CSII in six trials (RD 0.13, 95% CI 0.05 to 0.21, P = 0.002, I 2 = 30%), and compared with PLGS in two trials (RD 0.15, 95% CI 0.01 to 0.30, P = 0.04, Previous meta-analyses focused on the comparison between SH and SAP/CSII, and SH showed favourable effects both overnight and over a 24-hour period. 7,8,37,38 Our study showed that DH had a favourable effect compared with SAP/CSII. Two studies demonstrated that DH use was associated with a greater improvement in time in target range compared with SH in subgroup analysis, 7,8 which is inconsistent with our meta-analysis; however, our study included more trials, performed a head-to-head comparison, and was more reliable.…”