Efficacy and Safety of Cell-Assisted Lipotransfer

Zhou, Yiwen; Wang, Jing; Li, Haizhou; Liang, Xiao; Bae, Jinhong; Huang, Xiaolu; Li, Qingfeng

doi:10.1097/prs.0000000000001981

Cited by 107 publications

(61 citation statements)

References 37 publications

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“…However, there has been no objective assessment of the evidence in this area. Limited examples of secondary research have been published examining CAL for multiple indications,16, 17 but no studies focus exclusively on breast-related procedures. In light of this and the prospective role of CAL in breast augmentation and reconstruction, this systematic review was conducted to assess the efficacy and safety of cell assisted lipotransfer in breast surgery.…”

Section: Introductionmentioning

confidence: 99%

Cell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study quality

et al. 2016

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BackgroundCell assisted lipotransfer serves as a novel technique for both breast reconstruction and breast augmentation. This systematic review assesses the efficacy, safety and use of patient reported outcome measures in studies involving cell assisted lipotransfer. We also carry out an objective assessment of study quality focussing on recruitment, follow-up and provide an up-to-date clinical trial landscaping analysis.MethodsKey electronic databases were searched according to PRISMA guidelines and pre-defined inclusion and exclusion criteria. Two independent reviewers examined the retrieved publications and performed data extraction.Results3980 publications were identified. Following screening, 11 studies were included for full review, representing a total of 336 patients with a follow-up time ranging from six to 42 months. A degree of variation was noted in graft retention and reported satisfaction levels, although there were only three comparative studies with conflicting results. Complications occurred at a rate of 37%. Additionally, there was a paucity of objective outcomes assessments (e.g. 3D assessment modalities or validated patient reported outcome measures) in the selected studies.ConclusionsCell assisted lipotransfer is a surgical technique that is currently employed sparingly within the plastic & reconstructive surgery community. Presently, further technical and outcome standardization is required, in addition to rigorous randomized controlled trials and supporting long-term follow-up data to better determine procedural safety and efficacy. Routine use of more objective outcome measures, particularly 3D assessments and validated patient reported outcome measures, will also help facilitate wider clinical adoption and establish procedural utility.

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Section: Introductionmentioning

confidence: 99%

Cell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study quality

et al. 2016

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“…The mesenchymal cells of the fat graft are thought to give prolonged analgesia by changing the microenvironment and the secretion of substances [671314]. In the literature, a resorption rate of 17% to 82% of the injected fat is reported [15], which could explain why repeated treatment is required.…”

Section: Discussionmentioning

confidence: 99%

Autologous Fat Grafting as a Last Resort for Unsustainable Pain in a Woman with Multiple Osteochondromas

2017

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Multiple osteochondromas (MO) is characterized by the formation of osteochondromas throughout the entire body. Although the evidence regarding its pathogenesis is well understood, no curative treatment for the disorder is available. Patients can be treated symptomatically by surgical removal of painful osteochondromas. Unfortunately, some patients still suffer from severe pain, even after surgery. We report on a case concerning a 48-year-old woman with a history of MO who presented with persistent pain after surgical removal of a symptomatic osteochondroma of the left scapula and multiple symptomatic osteochondromas of the left foot and trochanteric region. Several interventions to reduce the pain did not have any lasting effect. Subsequently, she was treated with autologous fat grafting (AFG). After each session she was pain-free for at least one year and reported only partial recurrence of the pain. This is the first case report describing AFG for the treatment of pain after both surgical removal of an osteochondroma and symptomatic osteochondromas in a patient suffering MO with promising results. The treatment is more effective and clearly continues to remain active longer than injection therapy or pain medication. Future studies are necessary to confirm our results.

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“…[2][3][4] Recent advances in cell therapy have highlighted the adipose tissue-derived stem cells (ASCs) potential, leading to the concept of enriched lipotransfer, containing higher quantities of these pluripotent cells, with proven benefits. 5 We have started to expand the SEFFI technique to non-purely aesthetic indications with encouraging results. As the management of such cases should first take into account the primary need of each situation, the quantity and place of injection are individually adjustable.…”

Section: Discussionmentioning

confidence: 99%

Autologous fat transfer with SEFFI (superficial enhanced fluid fat injection) technique in periocular reconstruction

Riesco

Abascal

Duarte³

et al. 2017

Orbit

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Efficacy and Safety of Cell-Assisted Lipotransfer

Abstract: Therapeutic, III.

Cited by 107 publications

References 37 publications

Cell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study quality

Cell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study quality

Autologous Fat Grafting as a Last Resort for Unsustainable Pain in a Woman with Multiple Osteochondromas

Autologous fat transfer with SEFFI (superficial enhanced fluid fat injection) technique in periocular reconstruction

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