Efficacy and Safety of Celecoxib in the Treatment of Acute Pain due to Ankle Sprain in a Latin American and Middle Eastern Population

Celecoxib 2% Cream in Acute Soft Tissue Injuries: Randomized, Double-blind, Placebo-controlled Clinical Trial

“…Likewise, the results obtained were similar to those reported in previous studies with oral Celecoxib. For example, in a study with a population similar to ours in which the efficacy of Celecoxib 200 mg BID and NSAIDs was compared, it was shown that Celecoxib significantly reduced pain at day 7 when it was evaluated with a VAS score [20].…”

A randomized, double-blind, placebo-controlled multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel in the treatment of acute uncomplicated ankle sprain

“…17,[28][29][30][31][32][33][34][35][36] All of the more recent studies were randomized, double-blind, double-dummy, parallelgroup designs. 17,[28][29][30][31][32][33][34][35][36] Half of the studies were placebo-controlled, superiority studies. 17,29,30,34,35 The majority (nine studies) had pain-on-movement intensity difference from baseline (100 mm VAS) as the primary or secondary endpoint.…”

“…17,29,30,34,35 The majority (nine studies) had pain-on-movement intensity difference from baseline (100 mm VAS) as the primary or secondary endpoint. 17,[28][29][30][31][32][33]35,36 Seven studies assessed this endpoint on either day 3 or 4. [28][29][30][31][32]35,36 With the above limitations in mind, a comparison can be made on overall clinical outcome.…”

“…17,[28][29][30][31][32][33]35,36 Seven studies assessed this endpoint on either day 3 or 4. [28][29][30][31][32]35,36 With the above limitations in mind, a comparison can be made on overall clinical outcome. According to the review by Massey et al, 5 the proportion of participants experiencing successful treatment ('clinical success' defined as 50% reduction in pain or equivalent measure, such as 'very good' or 'excellent' global assessment of treatment, or none or slight pain-on-movement measured on a categorical scale) with a topical NSAID was 65% (range 31-100%) compared with 43% (range 8-83%) with placebo.…”

Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Acute Ankle Sprain

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) can also be used to reduce pain, decrease swelling, and improve short-term ankle function, thus speeding recovery (1,4,7,10,15,22). Topical NSAIDs, available "over-the-counter" in most countries, are proven effective and are particularly well tolerated for the short-term management of acute mildto-moderate pain and inflammation, including soft tissue injuries such as ankle sprains.…”