Efficacy and safety of cardiac shock wave therapy for patients with severe coronary artery disease: A randomized, double-blind control study

Jia, Na; Zhang, Ruisheng; Liu, Bing; Qi, Xin; Lan, Ming; Liu, Junmeng; Zeng, Ping; Chen, Congxia; Li, Wenchan; Guo, Yue; Yao, Zhiming; He, Qing

doi:10.1007/s12350-021-02768-7

Cited by 9 publications

(12 citation statements)

References 40 publications

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“…Then, 151 records were included for a more thorough review using the inclusion and exclusion criteria described in the methods. Finally, 10 records ( 11 , 21 – 29 ) were selected for review following the PRISMA statement. Among them, eight were RCTs and two were prospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Accumulating evidence has demonstrated that CSWT does not cause an increase in the levels of cardiac biomarkers (i.e., troponin I, troponin T, creatine kinase-MB, B-type natriuretic peptide) and has no adverse effects on blood pressure, heart rate, and oxygen saturation in patients with CAD. Serious complications, including malignant arrhythmia and embolism, have not been observed after CSWT ( 11 ). In Kagaya’s study ( 23 ), which enrolled 17 patients with AMI undergoing CSWT, 16 patients completed CSWT and survived 12 months after AMI without any adverse effects with only one patient dying of cardiac rupture independent of CSWT.…”

Section: Discussionmentioning

confidence: 99%

“…In Ceccon’s study ( 34 ), 15 patients with refractory angina receiving CSWT presented mild chest discomfort during treatment and with a rare appearance of major adverse effects related to CSWT. In Jia’s study ( 11 ), 15 patients diagnosed with severe CAD were treated with CSWT and no severe adverse effects occurred. Since shock wave carries low-intensity energy, there are several contradictions to CSWT, including acute pericarditis, acute myocarditis, infectious endocarditis, deep venous thromboembolism, intracardiac thrombus, severe aortic valve stenosis, thoracic aortic aneurysm, thoracic aortic dissecting aneurysm, cardiac transplantation, pulmonary embolism, and mechanical heart valve replacement ( 11 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, in clinical studies, investigations into the efficacy of CSWT on cardiac functions and myocardial perfusion have yielded inconsistent and conflicting results. Some studies demonstrated that CSWT could enhance left ventricular (LV) systolic function and alleviate myocardial ischemia ( 11 – 13 ), whereas others found that there were no significant associations between CSWT and cardiac function or myocardial perfusion ( 14 , 15 ). To address this issue, Burneikaitë et al ( 16 ) and Yang et al ( 17 ) performed meta-analyses in 2017 and 2020, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Shock Wave Therapy in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Qiu

Chen

Qiu

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveCoronary artery disease (CAD) has been one of the leading causes of morbidity and mortality worldwide. Cardiac shock wave therapy (CSWT) is a novel and non-invasive therapy for CAD. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy of CSWT on CAD.Methods and resultsWe performed a comprehensive search of electronic databases such as PubMed, Embase, the Cochrane Library, and Wanfang Data in October 2021. The results were reported as weighted mean difference (WMD) with a 95% confidence interval (CI). Statistical heterogeneity scores were assessed with the standard Cochran’s Q test and the I2 statistic. A total of 8 randomized trials and 2 prospective cohort studies, together involving 643 patients (n = 336 CSWT and n = 307 control), were included in our study. Eight studies with 371 patients showed significantly improved rest left ventricular ejection fraction (LVEF) with CSWT as compared to that of the control group (WMD 3.88, 95% CI 1.53–6.23, p = 0.001, I2 = 51.2%). Seven studies with 312 patients reported left ventricular internal diameter in diastole (LVIDd) were markedly decreased in the CSWT group compared to the control group (WMD −1.81, 95% CI −3.23 to −0.39, p = 0.012, I2 = 20.3%). The summed stress score significantly favored the CSWT group (WMD −3.76, 95% CI −6.15 to −1.37, p = 0.002, I2 = 56.8%), but there was no significant difference for the summed rest score. Our data were acquired from studies without a perceived high risk of bias, so plausible bias is unlikely to seriously affect the main findings of the current study.ConclusionBased on data from our present meta-analysis, CSWT was shown to moderately improve myocardial perfusion and cardiac function among patients with CAD, which would provide the clinicians with a meaningful and valuable option.Systematic Review RegistrationThe meta-analysis was registered on the Open Science Framework (OSF) (https://osf.io/r2xf9).

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiac Shock Wave Therapy in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Qiu

Chen

Qiu

et al. 2022

Front. Cardiovasc. Med.

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“…Those patients continued to experience restricted physical capacity and declining quality of life. There are some alternative strategies for those patients, such as coronary sinus reducer implantation [ 3 ], spinal cord stimulation [ 4 ], or cardiac shock wave therapy [ 5 ]; yet, the treatment efficacy is still limited. Coronary collateralizations are networks of arterial-to-arterial anastomotic connections that have the potential to provide blood supply against the ischemia injury caused by severely stenotic or even occluded coronary vessels [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Serum CTRP9 Reflects Coronary Collateralization in Nondiabetic Patients with Obstructive Coronary Artery Disease

Gao

Liu

et al. 2022

BioMed Research International

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Aim. To explore the association between the serum C1q/tumor necrosis factor-related protein 9 (CTRP9) and the formation of coronary collateral circulation in obstructive coronary artery disease (CAD). Methods. A total of 206 patients who underwent coronary angiography at Beijing Anzhen Hospital and had epicardial arteries with at least 95% stenotic lesion were enrolled. Blood samples were taken after an overnight fasting before the coronary angiography. Serum CTRP9 level was measured using commercial enzyme linked immunosorbent assay (ELISA) kit. The development of coronary collateralization was determined according to the Rentrop classification system. Rentrop score 0-1 was graded as impaired or less-developed coronary collateralization ( n = 54 ) while the Rentrop score 2-3 was defined as well-developed collateralization ( n = 152 ). Results. Serum CTRP9 level was significantly higher in well-developed collateralization and diabetes groups ( P < 0.001 ). To further explore the association between the CTRP9 level and coronary collateralization, the enrolled participants were divided into 3 tertiles according to the serum CTRP9 level. The prevalence of impaired coronary collateralization decreased stepwise with the increasing CTRP9 tertiles ( P for trend <0.001). Multivariate regression analysis showed that the serum CTRP9 is independently associated with well-developed collateralization, with an OR (95% CI) of 4.49 (1.75-11.55) and 8.98 (2.75-29.35) in the tertiles 2 and 3, respectively. The following subgroup and receiver-operating characteristic (ROC) analysis also indicated that the diagnostic value of serum CTRP9 level for detecting the formation of collateralization persisted only in nondiabetic participants. Lastly, adding the serum CTRP9 into the baseline model could increase the diagnostic value of established model consisting of relevant factor for the discrimination of well-developed collateralization only in the nondiabetic group ( P = 0.046 ). Conclusions. Serum CTRP9 reflects well-developed coronary collateralization in nondiabetic patients with obstructive CAD, and CTRP 9 level ≥ 1.217 indicated a greater chance to forming well-developed coronary collaterals.

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Is Cardiac Shock Wave Therapy an Option for the Treatment of Myocardial Ischemia in Patients with Refractory Angina?

Nudi

Tomai

2022

Journal of Nuclear Cardiology

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Efficacy and safety of cardiac shock wave therapy for patients with severe coronary artery disease: A randomized, double-blind control study

Cited by 9 publications

References 40 publications

Cardiac Shock Wave Therapy in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Cardiac Shock Wave Therapy in Coronary Artery Disease: A Systematic Review and Meta-Analysis

Serum CTRP9 Reflects Coronary Collateralization in Nondiabetic Patients with Obstructive Coronary Artery Disease

Is Cardiac Shock Wave Therapy an Option for the Treatment of Myocardial Ischemia in Patients with Refractory Angina?

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