Efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) on immune function enhancement: An 8 week, randomised, double-blind, placebo-controlled clinical trial

Lyu, Yee Ran; Jung, Sol-Ji; Lee, Su-Won; Yang, Won‐Kyung; Kim, Seung-Hyung; Jung, In Chul; Kim, Kun-Hoae; Kim, Han-Young; Yang, Yun Jeong; Lee, Yunhee; Yoon, Suk Ran; Park, Yang-Chun

doi:10.1016/j.jff.2020.104259

Cited by 6 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacological effects of Canavalia gladiata are reported for cancer [6], allergies [7], antioxidants [8], and inflammation [9]. Canavalia gladiata in complex with Arctium lappa extract is proposed to develop as a functional food for stimulating immunity [10]. Similarly, the seeds of Canavalia ensiformis are a source of proteins with biotechnological importance including ureases [11] and proteases [12].…”

Section: Introductionmentioning

confidence: 99%

Potential Importance of Molybdenum Priming to Metabolism and Nutritive Value of Canavalia spp. Sprouts

Okla

Akhtar

Alamri

et al. 2021

Plants

View full text Add to dashboard Cite

Molybdenum ions (Mo) can improve plants’ nutritional value primarily by enhancing nitrogenous metabolism. In this study, the comparative effects of seed priming using Mo were evaluated among sproutings of Canavalia species/cultivars, including Canavalia ensiformis var. gladiata (CA1), Canavalia ensiformis var. truncata Ricker (CA2), and Canavalia gladiata var. alba Hisauc (CA3). Mo impacts on growth, metabolism (e.g., nitrogen and phenolic metabolism, pigment and total nutrient profiles), and biological activities were assayed. Principal component analysis (PCA) was used to correlate Mo-mediated impacts. The results showed that Mo induced photosynthetic pigments that resulted in an improvement in growth and increased biomass. The N content was increased 0.3-fold in CA3 and 0.2-fold in CA1 and CA2. Enhanced nitrogen metabolism by Mo provided the precursors for amino acids, protein, and lipid biosynthesis. At the secondary metabolic level, phenolic metabolism-related precursors and enzyme activities were also differentially increased in Canavalia species/cultivars. The observed increase in metabolism resulted in the enhancement of the antioxidant (2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP)) and antidiabetic potential (Glycemic index (GI) and inhibition activity of α-amylase, and α-glucosidase) of species. The antioxidant activity increased 20% in CA3, 14% in CA1, and 8% in CA2. Furthermore, PCA showed significant variations not only between Mo-treated and untreated samples but also among Canavalia species. Overall, this study indicated that the sprouts of Canavalia species have tremendous potential for commercial usage due to their high nutritive value, which can be enhanced further with Mo treatment to accomplish the demand for nutritious feed.

show abstract

Section: Introductionmentioning

confidence: 99%

Potential Importance of Molybdenum Priming to Metabolism and Nutritive Value of Canavalia spp. Sprouts

Okla

Akhtar

Alamri

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…Arctigenin 4 significantly decreased both total and nuclear AR (a key modulator of growth and progression of prostate cancer) expression as well as reduced the expression of multiple growth factors (VEGF, EGF, NGF-β, TNF-α, FGF-β, and PDGF-BB) in tumor tissues, leading to downregulation of proliferative signaling and upregulation of apoptotic signaling in tumors [102]. Lappaol F 13 (PubChem CID: 73425459) is a compound purified from A. lappa seeds which has great anticancer potential on nude mice bearing xenografted tumors, as it suppressed tumor growth in mice by 54% and 64% at doses of 5 mg/kg/d and 10 mg/kg/d, respectively [103]. The anticancer effects of A. lappa extract and its bioactive metabolites are illustrated in Table 2.…”

Section: Anticancer Effectmentioning

confidence: 99%

“…Volunteers were divided into two groups (extract group and placebo group) with 50 volunteers in each receiving extract or placebo once daily for 8 weeks. The extract complex was safe, and improved immune function via enhancing natural killer cell activity through IL-10 expression [13]. A randomized, double-blind placebo-controlled trial was assessed to determine the effect of A. lappa, Angelica sinensis, Lithospermum erythrorhizon, and Sesamum indicum complex on H. pylori-infected volunteers.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Through numerous preclinical studies (in vitro and in vivo), burdock has been found to exhibit a plethora of biological activities and pharmacological functions, including anti-inflammatory [5], anti-constipation [6], anti-cancer [7], management of male erectile dysfunction [8], angiogenic [9], antioxidant [10], ameliorating cerebral ischemia [11], and proapoptotic and antiangiogenic effects against breast cancer cells [12]. These effects are mostly ascribed to its richness of arctiin (PubChem CID: 100528), arctigenin (PubChem CID: 28125531), pectin (PubChem CID: 441476), fructooligosaccharides, inulin (PubChem CID: 132932783), dicaffeoyl acids and fructofuranan [13], chlorogenic acid (PubChem CID: 1794427), cynarin (PubChem CID: 5281769) [14], and flavonoids (rutin (PubChem CID: 5280805), myricetin (PubChem CID: 5281672), quercetin (PubChem CID: 5280343), apigenin (PubChem CID: 5280443), and kaempferol (Pub-Chem CID: 5280863)) [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation