Efficacy and Safety of Banxia Formulae for Insomnia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Abstract

Objective. To systematically evaluate the efficacy and safety of Banxia (Pinellia Tuber) formulae in the treatment of insomnia compared with those of conventional western medicines. Methods. Randomized controlled trials (RCTs) evaluating the efficacy and safety of Banxia formulae in the treatment of insomnia were searched from the following databases: PubMed, Cochrane Library, EMBASE, the China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), and Wanfang database. The literature collected was from the time when the databases were established to April 2020. Quality assessment and meta-analysis were conducted by using Cochrane bias risk assessment tool and RevMan 5.2, respectively. Publication bias was assessed by Egger’s test. Results. Fourteen RCTs with 910 participants were identified. A total of 46 traditional Chinese medicines involving 2 different dosage forms were used in the included studies. Meta-analysis indicated that Banxia formulae had more significant effects on improving the total effective rate (RR = 1.23, 95% CI 1.16 to 1.31), Pittsburgh Sleep Quality Index (PSQI, MD = −1.05, 95% CI −1.63 to −0.47), and the TCM syndrome score (SMD = −0.78, 95% CI −1.18 to −0.39). Meanwhile, on reducing adverse events, Banxia formulae also showed an advantage (RR = 0.48, 95% CI 0.24 to 0.93). Conclusion. According to the current studies, the efficacy of Banxia formulae in the treatment of insomnia is better than that of the conventional western medicines, and its safety is relatively stable. However, due to the limitations of this study, further research and evaluation are needed.

Traditional East Asian Herbal Medicine for Post-Stroke Insomnia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…The effect size of the Chaihu-Longgu-Muli decoction (MD = −2.80, 95% CI −5.48, −0.13, p = 0.04) [66] was larger than that of our results, while the results of Xiao-yao-san (MD: −1.82; 95% CI −2.39 to −1.24; p < 0.001) [67] was similar to ours. However, those of Shumian capsules (MD = −0.50, 95% confidence interval (CI) = [−0.78, −0.22], p = 0.0005) [68] and the Banxia Formulae (MD = −1.05, 95% CI −1.63 to −0.47) [69] were smaller than our results. The population of these studies did not include patients with insomnia accompanied by diseases, such as PSI, but, rather, patients with primary insomnia or insomnia disorder were evaluated.…”

Complex Korean Medicine Treatment for Posterior Ankle Impingement Syndrome: Case Report

“…Additionally, the patient was given Saengganggeosamtang as she complained of difficulty sleeping. Saengganggeosamtang consists of 6 herbs among which Pinelliae rhizoma and Zizyphus Jujuba have been widely reported to improve sleep disorders by their sedative and anti-convulsive effects 19,20) . As well as sleeping problems, all of the patient's other body systems were broadly obtained to reach the most appropriate prescription.…”

The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023

“…That said, this is in the context of rating the original studies to be of low quality. There is also evidence, also from low‐quality original studies (Ji et al, 2021), that Saffron (Lian et al, 2022; Munirah et al, 2022), Viola odorata (Huang, Huang, et al, 2022) and diverse plant cocktails, from traditional Chinese medicine, may be effective to a low degree (Birling et al, 2020; Chen et al, 2022; Chen, Yi, et al, 2020; Fan et al, 2020; Li, Xu, et al, 2020; Lin et al, 2021; Wang et al, 2021; Wang, Ju, et al, 2020; Yang et al, 2019; Zhang, Liu, et al, 2019; Zhou et al, 2022). It is problematic for the authors of this guideline to evaluate these original studies, within the context of traditional Chinese medicine, as most of the original studies were not published in English language.…”