Efficacy and Safety of AYUSH-64 in COVID-19: A Systematic Review and Meta-Analysis

Kumar, Amit; Ahmed, Azeem; Mundada, Pallavi Suresh; Kumar, K V S Hari; Jameela, Sophia; Yadav, Babita; Khanduri, Shruti; Rao, Bcs; Srikanth, Narayanam

doi:10.2139/ssrn.4049618

Cited by 1 publication

(8 citation statements)

References 11 publications

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“…All systematic reviews identified specific tools for assessing risk of bias (RoB). Eleven studies 35,45,[46][47][48]55,[61][62][63]67,75 reported that studies had moderate to high reported RoB. Factors reported as contributing to high RoB included lack of information regarding blinding or randomization, problems with measurement of outcomes and selective reporting, selection bias, and small sample size.…”

Section: Systematic Reviewsmentioning

confidence: 99%

“…Fifteen reviews 37,39,42,43,46,47,51,52,54,58,60,65,68,70,73 indicated significant improvements in other laboratory measures, such as viral nucleic acid levels, inflammatory markers, and reverse transcription polymerase chain reaction (RT-PCR) negativity. Some studies 50,51,54,63,67,73 reported that there were no significant improvements in measures of viral clearance, 63 nucleic acid test, 50,51 or pro-inflammatory markers. 54,63…”

Section: Improvement In Imaging Laboratory Measurementsmentioning

confidence: 99%

“…Some studies 50,51,54,63,67,73 reported that there were no significant improvements in measures of viral clearance, 63 nucleic acid test, 50,51 or pro-inflammatory markers. 54,63…”

Section: Improvement In Imaging Laboratory Measurementsmentioning

confidence: 99%

“…Four systematic reviews reported on the effects of Ayurvedic medicine in the treatment of COVID-19. 38,63,67,71 The types of studies included were RCTs and quasi-RCTs. Herbal interventions included granules, decoctions, tablets, nasal drops, and injections.…”

Section: Systematic Reviews -Ayurvedic Medicinementioning

confidence: 99%

“…Herbal interventions included granules, decoctions, tablets, nasal drops, and injections. Studies included in the systematic reviews examined Ayurvedic herbal medicine as adjunct to standard care, 38,63,67,71 as a standalone treatment, 38,67 or compared with placebo or placebo plus Western medicine. 38 Dosage and interventions varied across the studies.…”

Section: Systematic Reviews -Ayurvedic Medicinementioning

confidence: 99%

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Herbal Medicine and COVID-19: An Umbrella Review

Oakes,

Saunders,

Lloyd

et al. 2023

CANDJ

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Background: Most systems of traditional medicine have been using herbal medicines to prevent and treat acute respiratory conditions and various other conditions for centuries. The aim of this project is to identify and examine the systematic and narrative reviews reporting on the therapeutic use of herbal medicines as it relates to the prevention and treatment of COVID-19 and long COVID. Methods: This paper is part of an umbrella review of studies related to natural health products and natural therapies for the prevention or treatment of COVID-19. It is a follow-up to a live review that was conducted by the World Naturopathic Federation between May 2022 and May 2023. PubMed and Google Scholar were searched for systematic and narrative reviews that met defined quality criteria. Results: Over half of the initial systematic reviews were excluded as they did not meet the inclusion and AMSTAR criteria. The final paper included 25 narrative reviews and 41 systematic reviews (SR), with half of the SRs reporting on the safety of herbal interventions. Various therapeutic properties of over 60 herbal medicines were outlined, some individually and most of them as part of herbal formula (combinations). Conclusion/Summary: Herbal interventions demonstrated statistically significant improved recovery in patients with COVID-19. The most common therapeutic properties identified were immunological properties, anti-inflammatory, anti- microbial, and antioxidant while the most frequently investigated herbs were Glycyrrhiza glabra/uralensis, Tinospora cordifolia, and Curcuma longa. More attention is needed on the regulation of herbal medicines, the quality of research, and the safety of herbal medicines.

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Section: Systematic Reviewsmentioning

confidence: 99%

Section: Improvement In Imaging Laboratory Measurementsmentioning

confidence: 99%

“…Some studies 50,51,54,63,67,73 reported that there were no significant improvements in measures of viral clearance, 63 nucleic acid test, 50,51 or pro-inflammatory markers. 54,63…”

Section: Improvement In Imaging Laboratory Measurementsmentioning

confidence: 99%