Efficacy and Safety of Ashwagandha (<i>Withania somnifera</i>) Root Extract in Improving Sexual Function in Women: A Pilot Study

Dongre, Swati; Langade, Deepak; Bhattacharyya, Sauvik

doi:10.1155/2015/284154

Cited by 55 publications

(41 citation statements)

References 24 publications

(28 reference statements)

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“…Besides, sexual function was among the secondary outcomes or sub-domains of various questionnaires. Since Ashwagandha is popular as Indian ginseng (24) and is often compared to ginseng in the scientific literature (44), the trials related to this plant that was consistent with the goal of the current study were included in this systematic review as well (45). In addition, it is stated that women suffer from different chronic diseases around the menopause.…”

Section: Materials and Methods Inclusion And Exclusion Criteriamentioning

confidence: 99%

Section: Quality Assessment and Data Extractionmentioning

confidence: 99%

“…Selection bias in all the studies was the low risk that resulted from the sufficient information in the type of randomization, n = 5 (45,(48)(49)(50)(51). Unclear selection bias was identified as a result of the limitation in the formation of allocation concealment methods (n = 5) (45,(48)(49)(50)(51). Blinding of personnel, participants, and outcome assessor (low performance bias, n = 5) (45,48-51), incomplete outcome data (low attrition bias, n = 2 (45,51) and high attrition bias, n = 3 (48-50)) and low reporting bias (both primary and secondary outcomes were reported n = 5) were the other criteria for assessing the risk of bias in the included studies.…”

Section: Quality Assessment and Data Extractionmentioning

confidence: 99%

“…Finally, five articles were selected (Figure 1). Two trials had a parallel design (45,51) while three studies used a crossover design (48)(49)(50). Participants in all the included studies were assigned into two groups.…”

Section: Selection and Characteristics Of The Included Studiesmentioning

confidence: 99%

“…High and low doses contained dried ginseng root powder and effective compounds, respectively. The studies belonged to different contexts including Korea (48-50), Sweden (51), and India (45). In one of the trials, an improvement of sexual function was reported in postmenopausal women by Korean red ginseng (KRG).…”

Section: Selection and Characteristics Of The Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function

Ghorbani

Mirghafourvand

2018

International Journal of Women’s Health and Reproduction Scienc

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Objectives: An increase in life expectancy results in the aging population growth. This study was designed to evaluate the efficacy and adverse events of ginseng that could be used as a herbal medicine in women with sexual dysfunction. Materials and Methods: The authors of this study searched Cochrane Library, MEDLINE, Web of Science, Embase, Scopus, ProQuest, Google Scholar, and Persian databases without a time limitation until May 2018 and examined all the randomized clinical trials (RCTs) that compared the effect of different types of ginseng on sexual function of menopausal women as compared to the placebo controls. The Cochrane risk of bias tool was used to assess the methodological quality of the included studies. The heterogeneity was determined using the I2 index. In addition, standardized mean difference (SMD) was used instead of mean differences (MD) and a random effect was reported instead of fixed effect in meta-analysis. Results: The eligibility criteria were found in five RCTs. All the included studies were placebo-controlled. Two trials had a parallel design while three studies used a crossover design. Although four trials indicated that ginseng significantly improved sexual function, they didn’t report any treatment effect compared to the placebo group. Based on the results of meta-analysis obtained from five studies including 531 women, there was no statistically significant effect of ginseng on female sexual dysfunction (FSD) compared to the placebo control group (SMD: 0.26; 95% CI: -0.26 to 0.76). Nonetheless, there was a considerable heterogeneity among the studies (I2 = 81%; P < 0.0001). Moreover, all the included studies assessed adverse events, but in three of the RCTs, there was no significant difference between the placebo and ginseng groups. Conclusions: The evidence regarding ginseng as a therapeutic agent for sexual dysfunction is unjustifiable. Rigorous studies seem warranted in this respect.

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Section: Materials and Methods Inclusion And Exclusion Criteriamentioning

confidence: 99%

Section: Quality Assessment and Data Extractionmentioning

confidence: 99%

Section: Quality Assessment and Data Extractionmentioning

confidence: 99%

Section: Selection and Characteristics Of The Included Studiesmentioning

confidence: 99%

Section: Selection and Characteristics Of The Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function

Ghorbani

Mirghafourvand

2018

International Journal of Women’s Health and Reproduction Scienc

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Safety and Efficacy of Ashwagandha ( Withania somnifera )

Mishra

Venkatachalapathy²,

Khanli

2017

Neuroprotective Natural Products

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Effect of standardized root extract of ashwagandha (Withania somnifera) on well‐being and sexual performance in adult males: A randomized controlled trial

Chauhan

Srivastava²,

Pathak³

2022

Health Science Reports

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Background and Aim: In Ayurveda, ashwagandha is a popular plant for promoting youthful energy, longevity, and overall well-being. It is also an excellent aphrodisiac herb that aids in the improvement and maintenance of normal sexual health. The present study aims to evaluate the effect of ashwagandha root extract on improving sexual health in adult males.Methods: In this 8-week randomized, double-blind, placebo-controlled study, we investigated the aphrodisiac property of an ashwagandha root extract in adult males.Fifty participants with lower sexual desire were randomly allocated to take 300 mg of ashwagandha root extract or placebo capsules twice daily. Outcomes were measured using the derogatis interview for sexual functioning-male (DISF-M) questionnaire, serum testosterone, serum prolactin, and short-form survey-36 quality of life questionnaire before and after the intervention.Results: Compared to placebo, ashwagandha root extract supplementation was associated with a statistically significant increase in the total DISF-M scores (mean difference −9.8; 95% confidence interval, −10.73 to −8.87; p < 0.0001; t-test). It was also associated with a statistically significant increase in serum testosterone levels (−66.52; −80.70 to −52.34; p < 0.0001; t-test). However, the prolactin level did not change after intervention in both the ashwagandha and placebo groups (−1.06; −2.78 to 0.66; p > 0.05). Conclusion:These findings suggest that ashwagandha demonstrated a significant subjective perception of sexual well-being and assisted in increasing serum testosterone levels in the participants.

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Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study

Cited by 55 publications

References 24 publications

A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function

A Meta-Analysis of the Efficacy of Panax Ginseng on Menopausal Women’s Sexual Function

Safety and Efficacy of Ashwagandha ( Withania somnifera )

Effect of standardized root extract of ashwagandha (Withania somnifera) on well‐being and sexual performance in adult males: A randomized controlled trial

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