2018
DOI: 10.1186/s12916-018-1066-y
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Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial

Abstract: BackgroundDespite decades of experience with praziquantel treatment in school-aged children (SAC) and adults, we still face considerable knowledge gaps relevant to the successful treatment of preschool-aged children (PSAC). This study aimed to assess the efficacy and safety of escalating praziquantel dosages in PSAC infected with Schistosoma haematobium.MethodsWe conducted a randomised, dose-finding trial in PSAC (2–5 years) and as comparator a cohort of SAC (6–15 years) infected with S. haematobium in Côte d’… Show more

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Cited by 20 publications
(36 citation statements)
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“…All the studies that we reviewed reported that praziquantel is e cacious against schistosomiasis in children under ve years. The lowest PZQ dose that was e cacious against schistosomiasis in this age group was 20 mg/kg [25,26]. All the studies reported on the PZQ dose of 40 mg/kg to treat schistosomiasis in this age group.…”
Section: Discussionmentioning
confidence: 95%
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“…All the studies that we reviewed reported that praziquantel is e cacious against schistosomiasis in children under ve years. The lowest PZQ dose that was e cacious against schistosomiasis in this age group was 20 mg/kg [25,26]. All the studies reported on the PZQ dose of 40 mg/kg to treat schistosomiasis in this age group.…”
Section: Discussionmentioning
confidence: 95%
“…All the studies we reviewed reported PZQ to be safe for use to treat schistosomiasis in children aged ve years old and below. The highest safe dose of PZQ reported was 60 mg/kg [25,26]. All the studies reported that there were no serious adverse events reported after treating schistosomiasis in children aged ve years and below with PZQ doses of between 20 mg/kg to 60 mg/kg.…”
Section: Discussionmentioning
confidence: 99%
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“…This dosage is supported by studies that have shown than increasing the dosage to 60mg/kg does not significantly increase the efficacy of the drug [19,46]. Under dosing below 40mg/kg will reduce the efficacy of the drug and below 20mg/kg the efficacy of the drug can be entirely lost [19]. A PZQ overdose beyond 60mg/kg is unsafe for children aged below five [14].…”
Section: Incorrect Dosingmentioning
confidence: 99%
“…WHO and studies on the safety and efficacy of PZQ in children aged below five recommend a PZQ dose of 40mg/kg [2]. This dosage is supported by studies that have shown than increasing the dosage to 60mg/kg does not significantly increase the efficacy of the drug [19,46]. Under dosing below 40mg/kg will reduce the efficacy of the drug and below 20mg/kg the efficacy of the drug can be entirely lost [19].…”
Section: Incorrect Dosingmentioning
confidence: 99%