Efficacy and safety of anticoagulation in non-malignant portal vein thrombosis in patients with liver cirrhosis

Artaza, T.; Lopes, Marcelo Barreto; Romero, M.; Gómez, Ana-Zaida; Cruz, G. de la; Sánchez, Juan José; González, Concepción; Gómez, R

doi:10.1016/j.gastre.2018.11.023

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…Several cohort studies have investigated the efficacy and safety of anticoagulation for the treatment of PVT in patients with cirrhosis 15,16,20,60,[70][71][72][73][80][81][82][83][84][85][86][87][88][89][90][91][92] (Table S1). However, most studies are retrospective with different inclusion criteria and coagulation regimens.…”

Section: Efficacymentioning

confidence: 99%

Current knowledge and management of portal vein thrombosis in cirrhosis

Senzolo

García–Tsao

García‐Pagán

2021

Journal of Hepatology

125

150

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Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis.

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Section: Efficacymentioning

confidence: 99%

Current knowledge and management of portal vein thrombosis in cirrhosis

Senzolo

García–Tsao

García‐Pagán

2021

Journal of Hepatology

125

150

View full text Add to dashboard Cite

show abstract

“…Furthermore, the overall bleeding rate was similar, but the rate of variceal bleeding was significantly lower ( P = .04) in patients receiving anticoagulants. Since this paper was published, a dozen, mainly retrospective studies have been published, largely confirming these findings in a total of 653 patients receiving anticoagulation, and including 312 patients who received anticoagulants compared to 251 patients who did not …”

Section: Recanalization Of the Thrombosed Portal Veinmentioning

confidence: 52%

“…34 Finally, an increasing number of studies have evaluated the most important issue, which is the impact of recanalization on survival and the need for liver transplantation. None of these studies except one 28 found any influence, 29,30,32,35,64,67 although univariate analyses often suggested that recanalization was favourable. On the other hand, several studies have suggested that anticoagulation therapy has an independently positive effect, regardless of recanalization or the severity of liver disease.…”

Section: In Patients With Cirrhosismentioning

confidence: 97%

“…Since this paper was published, a dozen, mainly retrospective studies have been published, largely confirming these findings in a total of 653 patients receiving anticoagulation, and including 312 patients who received anticoagulants compared to 251 patients who did not. [28][29][30][31][32]35,[64][65][66][67] These recent studies show the high risk of recurrence following discontinuation of anticoagulation (43% in 219 patients at risk). Even more interestingly, these studies provide data on additional points that are important for the interpretation of mainly morphological data.…”

Section: In Patients With Cirrhosismentioning

confidence: 99%

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