Efficacy and Safety of an Oral Formulation of Cetirizine and Prolonged-Release Pseudoephedrine versus Budesonide Nasal Spray in the Management of Nasal Congestion in Allergic Rhinitis

Abstract

Rhinomanometry and nasal cavity photos both indicated that cetirizine/pseudoephedrine efficacy was statistically superior to budesonide in the management of nasal congestion during VCC sessions. The efficacy of cetirizine/pseudoephedrine was similar to that of budesonide from the end of day 1 up to day 4 when individuals were exposed to their natural environment post exposure to the aeroallergens. This study confirms the efficacy of cetirizine/pseudoephedrine and budesonide in the management of nasal congestion associated with allergic rhinitis. Both medications were well-tolerated. Cetirizine/pseudoephedrine was more effective than budesonide during HDM exposure, whereas budesonide became as effective as cetirizine/pseudoephedrine several hours post exposure to the allergens.

Development and validation of an Allergen Challenge Theater for grass and ragweed

“…Ocular symptoms in both studies were in the range reported in the literature. 10 We have demonstrated that the ACT is able to generate reproducible pollen concentrations comparable to those seen in other facilities. Allergy symptoms in both grass and ragweed allergic patients were also induced with good reproducibility, but clearly illustrating the importance of subject selection and the time interval between the challenges.…”

Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence

“…37 In the Ontario and Vienna allergen exposure chambers, several medications have been tested (Table III). 26,27,[38][39][40][41][42][43][44][45][46][47][48][49][50][51] The Ontario chamber studies show the rapid onset of efficacy for azelastine and its combinations. There does not seem to be a difference between azelastine alone or in combination.…”

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

“…Studies have also demonstrated that once daily dosing of combination oral antihistamine‐oral decongestant medications are statistically equivalent to twice daily dosing with regard to symptom relief 2131,2132 and that different antihistamine‐decongestant combinations are statistically equivalent in improving symptom scores 2132–2136 . In some studies, oral antihistamine‐oral decongestant combination medications are reported to be superior to INCS with regard to improving AR symptoms, particularly nasal congestion 1488,2137,2138 . In contrast, cetirizine‐pseudoephedrine was not superior to xylometazoline nasal decongestant spray alone in improving nasal airflow and nasal obstruction symptoms 2139 (Table XI.B.10.a).…”