Efficacy and safety of an over-the-counter 1% colloidal oatmeal cream in the management of mild to moderate atopic dermatitis in children: a double-blind, randomized, active-controlled study

Lisante, Toni Anne; Nuñez, Chris; Zhang, Paul

doi:10.1080/09546634.2017.1303569

Cited by 12 publications

(18 citation statements)

References 13 publications

(11 reference statements)

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“…On the other hand, brief hot showers have shown itch-relieving effects in experimental studies applying heat to chronic pruritus and atopic skin (142,143). Also, lukewarm baths with colloidal oatmeal may restore skin barrier and sooth pruritus (144). Moisturisers with water and liquid paraffin base are used in soothing creams and emulsions.…”

Section: Therapy: General Principles Including Emollientsmentioning

confidence: 99%

European S2k Guideline on Chronic Pruritus

Weißhaar¹,

Szepietowski²,

Dalgard³

et al. 2019

Acta Derm Venerol

242

201

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ActaDV is a journal for clinical and experimental research in the field of dermatology and venereology and publishes highquality papers in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of review articles in special areas, as well as Correspondence to the Editor to stimulate debate. New books are also reviewed. The journal has rapid publication times.

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Section: Therapy: General Principles Including Emollientsmentioning

confidence: 99%

European S2k Guideline on Chronic Pruritus

Weißhaar¹,

Szepietowski²,

Dalgard³

et al. 2019

Acta Derm Venerol

242

201

View full text Add to dashboard Cite

show abstract

“…48 In line with this, in one double-blind, randomized, activecontrolled study, Lisante et al recently reported over-thecounter 1% colloidal oatmeal cream is as effective as a prescription barrier cream for the symptomatic treatment mild-to-moderate atopic dermatitis in children. 10 In contrast to these findings, one French prospective study found oat sensitization is higher than expected in children with atopic dermatitis. 49 These discrepancies can be partially justified by the methodological flaws in French study which used oat pollen for skin prick tests and IgE testing.…”

Section: Discussionmentioning

confidence: 83%

“…9 Oatmeal possesses potent antioxidant and antiinflammatory properties that its clinical benefits in the treatment of a variety of inflammatory dermatologic disorders such as atopic dermatitis, psoriasis, and dry skin have been shown in the previous studies. [10][11][12] The active ingredients in oatmeal consist of polysaccharides, proteins, lipids, saponins, enzymes, flavonoids, vitamins, and avenanthramides. Avenanthramides are phenolic compounds present in oats that mediate its anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

<p>The Efficacy of Colloidal Oatmeal Cream 1% as Add-on Therapy in the Management of Chronic Irritant Hand Eczema: A Double-Blind Study</p>

Sobhan

Hojati

Vafaie

et al. 2020

CCID

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Background: Irritant contact dermatitis (ICD) is the most frequent cause of hand eczema (HE). There is promising evidence with the use of topical oatmeal compounds in the management of inflammation-and itch-responses associated with diverse dermatologic conditions. This study aimed to evaluate the clinical benefit of colloidal oatmeal cream in the management of chronic irritant HE. Methods: From October 2018 to November 2019, 79 patients with diagnosis of chronic irritant HE were allocated into either intervention or control groups by block randomization method. Besides fluocinolone 0.025% ointment for the first 2 weeks of treatment period, patients in the intervention and control groups were asked to use colloidal oatmeal 1% cream or base cream for additional 4 weeks as monotherapy. Changes in the HE severity based on the hand eczema severity index (HESCI) score, pruritus severity based on the visual analogue scale (VAS), and impact of skin disorder on patients quality of life based on the Dermatology Life Quality Index (DLQI) from baseline to weeks 2, 4, and 6 were assessed in the study groups. Results: Fifty subjects, 26 in intervention and 24 in control, completed the course of the study. The results indicated, though relatively comparable decrease in mean HESI and VAS scores was observed in both groups by the end of week 2, thereafter until end of the study a non-return of symptoms to baseline conditions was observed in the intervention group, while there was a significant return of symptoms to baseline conditions in the control group (p value<0.001 in both conditions). Further, a noticeable improvement in the DLQI score was seen in the intervention group compared with the control group (p value<0.001). Conclusion: Findings demonstrate that colloidal oatmeal, a natural product with proven barrier protection, moisturization, anti-inflammatory, and soothing properties, can have ameliorative effects on eczema severity symptoms in patients with chronic irritant HE.

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“…Studies included within the systematic review mostly ranged from ''low risk'' to ''some concerns,'' with one ''high risk study'' (Fig 1, Table I). [5][6][7][8][9][10][11][12][13] The Egger's test grouped by treatment showed no bias for aloe vera (AV) or turmeric. Bias was present for green tea (GT); however, further analysis through the ''fill and trim'' publication bias technique 14 deemed no publication bias.…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

“…Eczema area and severity index in AD. One study that included 68 patients with AD examined the efficacy of treatment with CO 13 (Table III). The primary outcome measured was improvement of the eczema area and severity index score.…”

mentioning

confidence: 99%

Complementary and alternative medicine treatments for common skin diseases: A systematic review and meta-analysis

et al. 2021

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Background Complementary and alternative medicine (CAM) treatments are growing in popularity as alternative treatments for common skin conditions. Objectives To perform a systematic review and meta-analysis to determine the tolerability and treatment response to CAM treatments in acne, atopic dermatitis (AD), and psoriasis. Methods PubMed/Medline and Embase databases were searched to identify eligible studies measuring the effects of CAM in acne, AD, and psoriasis. Effect size with 95% confidence interval (CI) was estimated using the random-effect model. Results The search yielded 417 articles; 40 studies met the inclusion criteria. The quantitative results of CAM treatment showed a standard mean difference (SMD) of 3.78 (95% CI [−0.01, 7.57]) and 0.58 (95% CI [−6.99, 8.15]) in the acne total lesion count, a SMD of −0.70 (95% CI [−1.19, −0.21]) in the eczema area and severity index score and a SMD of 0.94 (95% CI [−0.83, 2.71]) in the scoring of atopic dermatitis score for AD, and a SMD of 3.04 (95% CI [−0.35, 6.43]) and 5.16 (95% CI [−0.52, 10.85]) in the Psoriasis Area Severity Index score for psoriasis. Limitations Differences between the study designs, sample sizes, outcome measures, and treatment durations limit the generalizability of data. Conclusions Based on our quantitative findings we conclude that there is insufficient evidence to support the efficacy and the recommendation of CAM for acne, AD, and psoriasis.

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Efficacy and safety of an over-the-counter 1% colloidal oatmeal cream in the management of mild to moderate atopic dermatitis in children: a double-blind, randomized, active-controlled study

Cited by 12 publications

References 13 publications

European S2k Guideline on Chronic Pruritus

European S2k Guideline on Chronic Pruritus

<p>The Efficacy of Colloidal Oatmeal Cream 1% as Add-on Therapy in the Management of Chronic Irritant Hand Eczema: A Double-Blind Study</p>

Complementary and alternative medicine treatments for common skin diseases: A systematic review and meta-analysis

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