Efficacy and Safety of Amphotericin B       with Autologous Serum for Fungal Corneal Ulcer

Ji, Yongjing; Ji, Yongqiang; Zhang, Fang

doi:10.29271/jcpsp.2019.02.133

Cited by 1 publication

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“…Consequently, some patients may have the risk of blindness owing to missing of the best opportunity for treatment, which seriously affects their daily life and work. [3][4][5] At present, natamycin has been recognized to be the major therapeutic choice for FK. Natamycin has strong bactericidal and anti-fungal effects, which has been accepted as the first line drug for the treatment of FK.…”

Section: Introductionmentioning

confidence: 99%

Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis

Cai¹,

Yang²,

Wei

et al. 2023

Pak J Med Sci

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Objective: To observe the therapeutic effect of natamycin combined with voriconazole in the treatment of fungal keratitis (FK). Methods: This is a retrospective study. The subjects of this study were 64 patients with FK who were admitted to Baoding No.1 Central Hospital from February 2019 to July 2022. The enrolled patients were divided into control group (n= 32) and study group (n= 32) by the random number table method. The control group was treated with natamycin alone, and the study group was treated with natamycin combined with voriconazole. The total efficacy, time of disappearance of ocular symptoms, visual acuity level, keratitis severity score, corneal ulcer area, tear fungus index and incidence of adverse reactions were compared between the two groups. Results: The total efficacy,of the study group was significantly higher than that of the control group. The disappearance time of corneal ulcer, photophobia, foreign body sensation and hypopyon in the study group was shorter than those in the control group. Keratitis severity score and (1,3)-β-D-glucan level in the study group were lower than those in the control group. The corneal ulcer area was narrowed in the study group than that of the control group, and the visual acuity level in the former group was higher than that of the latter group. Besides, there was no significant difference in the frequency of adverse reactions between the two groups. Conclusion: Natamycin combined with voriconazole is safe and effective in the treatment of FK. doi: https://doi.org/10.12669/pjms.39.3.6908 How to cite this: Cai J, Yang C, Wei Q, Lian H, An L, Zhang R. Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis. Pak J Med Sci. 2023;39(3):775-779. doi: https://doi.org/10.12669/pjms.39.3.6908 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis

Cai¹,

Yang²,

Wei

et al. 2023

Pak J Med Sci

View full text Add to dashboard Cite

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Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer

Abstract: Objective: To observe the clinical efficacy and safety of injection therapy of amphotericin B combined with autologous serum in the treatment of fungal corneal ulcer.

Cited by 1 publication

References 14 publications

Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis

Natamycin versus natamycin combined with voriconazole in the treatment of fungal keratitis

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